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  1. M

    Excess Iron IBD

    Yes I remember this well. I think I will revisit and do some literature searching to see what I can come up with. You never know what you might find, for instance the lyme pathogen does not use iron, but manganese, but they have also found that claratin blocks uptake. Also this guy is correct...
  2. M

    Excess Iron IBD

    I still have great interest in the iron connection. This is a really comprehensive paper, they don't talk much about the small intestine, since they indicate that not all that much is known about what is going on with the gut bugs, in the small intestine. Anyhow I knew that lacto bacteria did...
  3. M

    Research into MAP as the cause of Crohn's

    Let me run this by everyone. One reason MAP and AIEC can survive inside macrophages is that either by immune subversion or some genetic defect, the phagasomes are not acidified enough. and low NO production possibly nos2 (macrophage inducible NO) and possibly arginine transport,or some form of...
  4. M

    Research into MAP as the cause of Crohn's

    Colicins, but finding the right probiotic seems somewhat difficult. Nissle 1917 might have been one, but that is taken off the market by the FDA. Old Mike http://www.ncbi.nlm.nih.gov/pubmed/26177305 here is something a little off the wall ecoli is rescued from colicin by B12, the receptor sites...
  5. M

    Receiving antibiotics during delivery affects infant gut bacteria

    Oh boy, this can't be good. Are you set up for IBD before you are born,in some cases. Old Mike https://www.med.ualberta.ca/departments/pediatrics/news/2015/november/receiving-antibiotics-during-delivery-affects-infant-gut-bacteria
  6. M

    MAP Vaccine Ready for Human Trials - Could be Used for Crohn's

    http://thecrohnsinfection.org/dr-william-chamberlin-fepibro/ here is what the compound is 16-bromoepiandrosterone http://thecrohnsinfection.org/dr-william-chamberlin/ it is an analog of DHEA, DHEA and DHEA-S are elevated in babies and seems to decrease in adulthood, but it varies with...
  7. M

    Primary manifestation of Inflammatory Bowel Disease (IBD) following subcutaneous autovaccination.

    I might work just like any other heat killed vaccine. Except now the immune response is against gut bacteria. Old Mike
  8. M

    Research into MAP as the cause of Crohn's

    Here is a video on crohns autoimmune or infectious https://www.youtube.com/watch?v=7x3lq8QEg5g&feature=youtu.be here is the lab site https://www.mcgill.ca/molepi/ Old Mike
  9. M

    Research into MAP as the cause of Crohn's

    New info from Brazil. Old Mike http://www.ncbi.nlm.nih.gov/pubmed/26176833 Presence of Mycobacterium avium subsp. paratuberculosis (MAP) in Brazilian patients with inflammatory bowel diseases and in controls. Carvalho IA1, Schwarz DG2, Pietralonga PA2, Faria AC2, Braga IF2, Carvalho GD3...
  10. M

    Here is why biologics may fail

    New info. MMP's can be activated by ROS/peroxides. MMP's deactivate biologics. Old Mike http://www.ncbi.nlm.nih.gov/pubmed/26170138
  11. M

    Best IBD microbiome/metabolic study I have ever found

    Not sure if ever posted before. Found it in an odd way, searching riboflavin and mucin. Highly complex, but you can now see a lot of what is going on in our guts. Its just not dysbiosis, the bugs are defending themselves from oxidative stress, and eating more mucus. Old Mike...
  12. M

    FECAL TRANSPLANTS: A Guide

    They finally released the whole paper on this FMT trial. I find it most interesting that they used autologous FMT as a control. Placebo effect a possible, shift in bacteria population in wrong direction yet still some remissions, what's really going on. Old Mike...
  13. M

    Landmark Crohn’s Microbiome Study Yields Important Findings

    Here is the complete paper, very interesting. Also notice in the conclusions they mention oxygen tension. The dysbiosis is a lot of aerobes and facultative anaerobes. Old Mike http://www.sciencedirect.com/science/article/pii/S1931312814000638 just in case the first link stops working...
  14. M

    Primary manifestation of Inflammatory Bowel Disease (IBD) following subcutaneous autovaccination.

    Well it seems they have been doing this for over 100 years,in Germany. Old Mike short version http://www.autovaccine.de/ND/english/autogenous_vaccines.html Long version http://www.old-herborn-university.de/publications/books/OHUni_book_15_article_9.pdf
  15. M

    Primary manifestation of Inflammatory Bowel Disease (IBD) following subcutaneous autovaccination.

    Its a holy crap, what is going on here. I can guess none of us have done this. But what happens prior to IBD if say you have a bleeding hemi. Or just a hard stool that scrapes off the mucus layer, and you bleed and the immune system can sample all the bacteria in the stool,or is this person a...
  16. M

    FECAL TRANSPLANTS: A Guide

    Here is a new FMT study out of China, its small but goes into adverse effects. Enjoy. Old Mike http://www.ncbi.nlm.nih.gov/pubmed/26080819
  17. M

    Pathogenesis of Crohn's disease: Bug or no bug

    I missed this one which is pretty new. Also remember my thread that just about all the IBD drugs suppress MAP, even biologics. Well here is more proof and just not test tube samples, on biologics. Notice where it says Infliximab treatment resulted in decreased MAP detection. I really have to...
  18. M

    Chronic Wounds and Biofilms in IBD

    Here is the whole email I got back from him. The main problem is an impaired mucus barrier: http://www.charite.de/arbmkl/themen/ubersicht/intestinalmicrobiota.pdf http://www.charite.de/arbmkl/publikationen/2010france.pdf Biofilms are secondary. Ulcereative colitis is ususally easy to cure...
  19. M

    FECAL TRANSPLANTS: A Guide

    Believe I posted this before. These 3 people got up to 30 rounds of FMT, but all relapsed eventually. What went wrong, perhaps oral is a better way to do it. Old Mike Serial Fecal Microbiota Transplantation Alters Mucosal Gene Expression in Pediatric Ulcerative Colitis Not even a dam...
  20. M

    FECAL TRANSPLANTS: A Guide

    If you use tap water to make saline it will contain oxygen. Cant find specific link. But even boiled water left sitting around will absorb oxygen from the air. If you mix the poo in a blender like many do, then lots of oxygen. If you mix in a baggie then best to squeeze out the air. If part of...
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