I've been 2 months on prednisone starting at 40mg and now I'm down to 25mg but I haven't gained weight, in fact I've maintained and I'm consuming 2,500-3,000 calories daily from nutritional shakes. Is prednisone different for others? People often say they gain a lot of weight from the prednisone side effects so I'm confused. Other than acne on my chest and headaches I don't really have much side effects.