I've been on 6MP since September...started with 50mg. 5 weeks ago the dose was upped to 75mg. I had sore throats as well, but after my GP (not my GI believe it or not) suggested that sore throats sometimes symbolize acid reflux. I was put on Prilosec 20mg daily and my sore throats magically went away. As a nice aside, I was once again able to indulge in tomatoes without heartburn! Otherwise, my experience with 6MP is quite similar to others...had strep, sinus infection, and a bad cold ever since I started with it and now the fatigue is just unbelieveable. But I was told by several GI's that its a fantastic drug but it takes some time for it to really take effect on the Crohns symptoms (4-6 weeks). So, though I'm not in remission yet, the 6MP is definitely helping make this more managable, even with the side effects. Hope this helps and you should feel good soon!