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A Genome-Wide Association Study Identifies 2 Susceptibility Loci for Crohn’s Disease in a Japanese Population
http://www.gastrojournal.org/article/S0016-5085%2812%2901847-1/abstract
A Genome-Wide Association Study Identifies 2 Susceptibility Loci for Crohn’s Disease in a Japanese Population
Keiko YamazakiJunji UmenoAtsushi TakahashiAtsushi HiranoTodd Andrew nson
,atsuhiko KumasakaTakashi MorizonoNaoya HosonoTakaaki KawaguchiMasakazu TakazoeTetsuhiro YamadaYasuo SuzukiHiroki TanakaSatoshi MotoyaMasayo HosokawaYoshiaki ArimuraYasuhisa ShinomuraToshiyuki MatsuiTakayuki MatsumotoMitsuo IidaTatsuhiko TsunodaYusuke NakamuraNaoyuki KamataniMichiaki Kubo
Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN, Yokohama, Japan.
December 2012
Background & Aims
Crohn’s disease is an inflammatory bowel disease induced by multiple genetic and environmental factors. Genome-wide association studies have identified genetic factors that affect risk for Crohn’s disease in European populations, but information from other ethnic groups is scarce. We therefore investigated genetic factors associated with Crohn’s disease in the Japanese population.
Methods
We performed a genome-wide association study with 372 individuals with Crohn’s disease (cases) and 3389 controls, all from the Japanese population. To confirm identified associations, we performed a replication study with an independent panel of 1151 Crohn’s disease cases and 15,800 controls. We also performed an association analysis using genome-wide genotype imputation in the discovery cohort.
Results
We confirmed associations of Crohn’s disease with variants inMHC (rs7765379,P = 2.11 x 10-59),TNFSF15 (rs6478106,P = 3.87 x 10-45), andSTAT3 (rs9891119,P = 2.24 x 10-14). We identified 2 new susceptibility loci, on chromosome 4p14 (rs1487630,P = 2.40 x 10-11, odds ratio = 1.33) and in theSLC25A15-ELF1-WBP4region on 13q14 (rs7329174 in ELF1,P = 5.12 x 10-9, odds ratio = 1.27).
Conclusions
In a genome-wide association study, we identified 2 new susceptibility loci for Crohn’s disease in a Japanese population. These findings could increase our understanding of the pathogenesis of Crohn’s disease.
http://www.gastrojournal.org/article/S0016-5085%2812%2901847-1/abstract
A Genome-Wide Association Study Identifies 2 Susceptibility Loci for Crohn’s Disease in a Japanese Population
Keiko YamazakiJunji UmenoAtsushi TakahashiAtsushi HiranoTodd Andrew nson
,atsuhiko KumasakaTakashi MorizonoNaoya HosonoTakaaki KawaguchiMasakazu TakazoeTetsuhiro YamadaYasuo SuzukiHiroki TanakaSatoshi MotoyaMasayo HosokawaYoshiaki ArimuraYasuhisa ShinomuraToshiyuki MatsuiTakayuki MatsumotoMitsuo IidaTatsuhiko TsunodaYusuke NakamuraNaoyuki KamataniMichiaki Kubo
Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN, Yokohama, Japan.
December 2012
Background & Aims
Crohn’s disease is an inflammatory bowel disease induced by multiple genetic and environmental factors. Genome-wide association studies have identified genetic factors that affect risk for Crohn’s disease in European populations, but information from other ethnic groups is scarce. We therefore investigated genetic factors associated with Crohn’s disease in the Japanese population.
Methods
We performed a genome-wide association study with 372 individuals with Crohn’s disease (cases) and 3389 controls, all from the Japanese population. To confirm identified associations, we performed a replication study with an independent panel of 1151 Crohn’s disease cases and 15,800 controls. We also performed an association analysis using genome-wide genotype imputation in the discovery cohort.
Results
We confirmed associations of Crohn’s disease with variants inMHC (rs7765379,P = 2.11 x 10-59),TNFSF15 (rs6478106,P = 3.87 x 10-45), andSTAT3 (rs9891119,P = 2.24 x 10-14). We identified 2 new susceptibility loci, on chromosome 4p14 (rs1487630,P = 2.40 x 10-11, odds ratio = 1.33) and in theSLC25A15-ELF1-WBP4region on 13q14 (rs7329174 in ELF1,P = 5.12 x 10-9, odds ratio = 1.27).
Conclusions
In a genome-wide association study, we identified 2 new susceptibility loci for Crohn’s disease in a Japanese population. These findings could increase our understanding of the pathogenesis of Crohn’s disease.
