Saw my GI today. He asked me to try this new release style of mesalamine called APRISO. It is release in the colon instead. Well seeing I need to get off the prednisone ASAP due to this Osteoperosis that I just got. I hope it works and I don't get side effects like the Asacol tried 2 years ago. I am interested in anyone who is on this and or has tried this to see how it worked for them and if they had any side effects.