Buspirone as treatment for Crohn's

[fish]

Does anyone here have experience with or knowledge of the use of Buspirone as a treatment for active Crohn's? I have found some older scientific/medical papers on this but nothing recent. It is an off label use of the drug and I wanted to get more information about it if there is any available. Any research/documents/etc you can point me to would be greatly appreciated.

 

[my little penguin]

Is your Gi prescribing this ?
It’s an anti-anxiety med.

 

[fish]

Yes, GI prescribed but not for anxiety. Currently not on treatment and pain levels are really bad. To help with pain until I can begin treatment again. Some articles if you are interested. Have to dig through but seem to suggest some upside:

https://www.nature.com/articles/s41598-021-85681-w
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977648/
https://academic.oup.com/ibdjournal/article/25/5/886/5247629
https://www.google.com/amp/s/amp.cn...sants-bowel-crohns-disease-partner/index.html
https://pubmed.ncbi.nlm.nih.gov/32967429/

 

[Jbungie]

I was also reading about this a few weeks ago, pretty interesting stuff. I believe the Doc's name that was studying it is Richard Kast.

Remission of Crohn's disease on bupropion - Gastroenterology (gastrojournal.org)

Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice | Scientific Reports (nature.com)

 

[Jbungie]

Also interesting, I've been taking this drug for anxiety for 7 years. Have had routing blood work done 4 times in the past 4 years, and every time my WBC count has come back below the lowest end of normal. It was 2.7 and 3.0 last 2 times. I just had a blood draw for this from a hemotologist last week to make sure nothing else was going on. Only side effects I have every had with Buspar were dizziness. I am on a low dose of 10mg a day.

I'd be very interested in hearing if you doctor has had success with using this off label. Please inquire more. My 5yo son was diagnosed with IBD in January.

 

[fish]

Also interesting, I've been taking this drug for anxiety for 7 years. Have had routing blood work done 4 times in the past 4 years, and every time my WBC count has come back below the lowest end of normal. It was 2.7 and 3.0 last 2 times. I just had a blood draw for this from a hemotologist last week to make sure nothing else was going on. Only side effects I have every had with Buspar were dizziness. I am on a low dose of 10mg a day.

I'd be very interested in hearing if you doctor has had success with using this off label. Please inquire more. My 5yo son was diagnosed with IBD in January.

If I learn more I will keep you posted.