Endocannabinoid overactivity and intestinal inflammation

[Crohn2357]

Endocannabinoid overactivity and intestinal inflammation
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1856409/

 

[7vNH]

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It appears that endocannabinoids might regulate the intestinal response to inflammation at three levels: (1) reducing the release of neurotransmitters that affect intestinal motility and secretion; (2) directly suppressing the production of proinflammatory mediators such as TNF‐α; and (3) promoting epithelial wound healing (fig 1​)
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In conclusion, there is great potential for the development of new therapeutic agents against intestinal inflammation from the endocannabinoid system. While full understanding of the mechanisms of the anti‐inflammatory actions of cannabinoid receptor activation is still to be pursued, ad hoc clinical studies will ascertain whether the promising results obtained in animals can be extrapolated to the clinic.