Hey have you noticed any bowel changes? I've gotten constipation for the first time in about 25 years. It's odd. Not sure if it's just the narrow TI or Envivo.I have my 6th tomorrow. They normally need 20 minutes minimum to mix the drug, which they don't start until you get there, and sometimes until after you are hooked up. I have no side effects that I can say are because of Entyvio- anything I have I had before. Normal old age aches & pains.