Environmental risk factors in Crohn's disease and ulcerative colitis: an update.

[Crohn2357]

Environmental risk factors in Crohn's disease and ulcerative colitis: an update.
http://www.ncbi.nlm.nih.gov/pubmed/20117338
http://www.em-consulte.com/showarticlefile/237394/main.pdf (Full text)

 

[7vNH]

Gastroentérologie Clinique et Biologique (2009)

To date, three theories integrate envi-
ronmental factors to pathogenesis of IBD: hygiene (It theorizes that a lack of expo-
sures to enteric pathogens makes one susceptible to CD), infection (Several studies suggest that infection plays a prominent role
in IBD) and cold chain (the plague epidemic which struck Europe ...provided increased resistance to this disease. Some bacteria ...survive in refrigerators).

Everyone should read this paper!

 

[wild_one353]

Tobacco may be an anti-inflammatory, which is responsible for both the observation of it being both protective and a risk factor in UC. well in my opinion this may explain the observations, how can it be both "protective" and a risk factor? quitting smoking lets the disease symptoms emerge because they were being supressed by tobacco, at least that's my theory.

I would just refer to the new information that we have showing less diversity in microbiome, there are more risk factors like sucralose that arent in this paper.

 

[7vNH]

.....

I would just refer to the new information that we have showing less diversity in microbiome, there are more risk factors like sucralose that arent in this paper.

Agreed...I wish this kind of review was repeated with all of the current information.

Talking about tobacco and UC....are there any papers that do a nicotine patch vs placebo patch in UC? The paper in this thread said something about a carbon monoxide mechanism that reduced UC, so that aspect would not be present in a nicotine patch. But if it meant reduced/eliminatef symptoms, I imagine many UC sufferers would use a patch.