I have a large fissure. I also have Crohns. I know Crohns fissures are more complex than fissure in healthy person. I don't have any other Crohns symptoms besides a fistula I've had for 10 years. I believe I developed fissure after a colonoscopy a few months ago. It has been basically debilitating as there is severe pain all day. The only time it feels a little better is when I'm sleeping. I have been using 2 prescription ointments for over a month now plus baths and heating pads. My colorectal surgeon said surgery will only make it worse and she thinks Humira will help, but my GI said my CRS will have to deal with the fissure. What other options do I have? I am literally laying down much of the day because of the pain of sitting or standing