High dose Mtx reduces humira antibodies

[my little penguin]

http://www.internalmedicinenews.com...duction/1a0aecf9942a538c0d9225ee8d135725.html

During 3 years of follow-up, 76 patients (28%) developed a significant immune response to the adalimumab, accounting for half of those getting no methotrexate, 35% of patients on a low methotrexate dose, 22% on an intermediate dose, and 14% on a high dose.

An odds ratio analysis showed that low-dose methotrexate cut the frequency of immune responses by 64%, an intermediate dose cut the incidence of antibody production by 78%, and high dose cut the rate by 86% compared with no methotrexate, all statistically significant differences. Only high doses of methotrexate significantly cut the rate of antibody production compared with low doses.

Methotrexate Cuts Anti-Adalimumab Antibody Production
07-11-2012 10:50
By: MITCHEL L. ZOLER, Internal Medicine News Digital Network


AT THE ANNUAL EUROPEAN CONGRESS OF RHEUMATOLOGY

 

[my little penguin]

In patients with juvenile idiopathic arthritis, adalimumab antibodies were identified in 16% of HUMIRA- treated patients. In patients receiving concomitant methotrexate, the incidence was 6% compared to 26% with HUMIRA monotherapy

From:
http://www.humirajustice.com/pdf/fda/29_mar2011_6.1_liverfailure.pdf

 

[Clash]

What is considered high dose?

Btw, I've been ecstatic about how C feels but I foulnd out today my Mom(who is on MTX and Remi) got her lab work back and liver enzymes are really elevated. She has RA, and is on 20mg of MTX and just dropped down to 15 before this lab work. She goes back for more lab work on Monday. Blech...it just turns my stomach to think it could affect C at his higher dose.

 

[my little penguin]

20 mg is high dose
2.5 mg is low dose

 

[Dexky]

W/O me having to burn my brain cells trying to understand a bunch of medical jargon, does the report say anything about mtx reversing abs that have already appeared?

 

[my little penguin]

Typically once you have antibodies they don't go away
The report says nothing about reducing them

 

[crohnsinct]

I hear ya Clash! That is my one big concern with stupid Mtx...the liver! Given my family history with liver issues I am just waiting for the day. But at least there is something they can do about it and from what I read the liver damage hits at a cumulative amount and hopefully a new drug or cure will come out before our kids hit that cumulative total.