How biologics are delivered into system?

[nogutsnoglory]

We inject biologics into our fat. Don't you need to inject in the vein so the medicine travels around? How can the meds ever leave the fatty portion where we injected it?

Obviously it works since that's what we are supposed to do but I'm curious.

 

[Misty-Eyed]

Well in an ideal world, all biologics... Monoclonal antibodies.. Would be given by subcutaneous injection as its easier, cheaper and quicker to deliver to the patient but only some can due to limited uptake of the drug in the body. The drugs from a subcutaneous injection are absorbed into the surrounding blood vessels at a slower rate. I'm not sure how up on your science you are, but I found this article pretty interesting http://www.isdbweb.org/documents/file/1442_2.pdf

 

[nogutsnoglory]

So they are being dispersed into the blood system but at a slower rate? Wouldn't that mean remicade would work faster than humira or cimzia since its through IV? It doesn't though so I find that confusing.