When I first took Lialda, it cleared up all problems right away, but I was in the hospital with a bad flu a few months ago, got lots of antibiotics, and haven't been back to perfect yet. It keeps me down to 2 or 3 bms a day, not D, but not firm. My CRP was 0 on Lialda before the flu, but now it's 9.2, so the dr might say i have to try something else. I don't know yet. I did have mild headaches at first, but now I take them before bed, so that's okay.