I had occassional issues with my humira injections at the beginning. I would break hives on an area of about the size of a golf ball around the site I injected. It was mostly happening on thighs, rarely on belly. It was doing that when the med was actually working. My theory is that your body is "reacting" to it, and reacting might means producing more antibodies to it, and that is not ideal to produce antibodies to Humira. My reasoning might be wrong but this is my theory as a patient. The reaction itself should not be too problematic if it resolves quickly enough (that's how my GI reacted when I mentionned it) as it seems to be fairly frequent but I think it worths considering the "why" its happenning.
