Increased frequency of intestinal CD4+ T cells reactive with mycobacteria in patients with Crohn's disease

[kiny]

http://informahealthcare.com/doi/abs/10.3109/00365521.2013.837952

November 2013

Centre for Immune Regulation and Department of Immunology, Oslo University Hospital-Rikshospitalet, Norway

Ingrid Olsen, Knut E Lundin,Ludvig M Sollid

Increased frequency of intestinal CD4+ T cells reactive with mycobacteria in patients with Crohn's disease

 

[kiny]

Changed it to full document. Think it's easier to read than going through links.

 

[D Bergy]

I will personally vouch for their findings.

Dan

 

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I think these bacteria increase specific immune to kill other bacteria without itself to colonize

 

[kiny]

Don't know. I don't think the bacterial flora is really that important in crohn's disease, genes, peyer's patches, transmural inflammation, fistula, an adaptive immune response that requires an APC, that's only possible with an intracellular bacteria. Not with some "uncontrolled response to the human flora", makes no sense. You don't get this type of inflammation unless a bacteria has penetrated the gut wall and set off an antigen presenting cell that can travel up to the lymph system, that is not going to happen without an intracellular pathogen.

The granuloma in crohn's disease also look like intestinal TB, the inflammation does not look like UC.

That was Dalziel's first assumption, that the patients had intestinal TB, since it very much looked like intestinal TB when crohn's disease was first seen, and all those patients were checked for TB.