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https://news.weill.cornell.edu/news/2024/05/common-type-of-fiber-may-trigger-bowel-inflammation
Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University
Mohammad Arifuzzaman,Tae Hyung Won,Hiroshi Yano,Jazib Uddin,
Elizabeth R. Emanuel,Elin Hu,Wen Zhang,Ting-Ting Li,Wen-Bing Jin,Alex Grier,Sanchita Kashyap,Chun-Jun Guo,Frank C. Schroeder,David Artis
May, 2024
Inulin, a type of fiber found in certain plant-based foods and fiber supplements, causes inflammation in the gut and exacerbates inflammatory bowel disease in a preclinical model, according to a new study by Weill Cornell Medicine investigators.
The surprising findings could pave the way for therapeutic diets that may help ease symptoms and promote gut health.
He and his colleagues expected that inulin would also have protective effects in inflammatory bowel disease. But they found just the opposite.
Feeding inulin to mice in the context of a model of inflammatory bowel disease increased the production of certain bile acids by specific groups of gut bacteria. The increased bile acids boosted the production of an inflammatory protein called IL-5 by ILC2s. The ILC2s also failed to produce a tissue-protecting protein called amphiregulin. In response to these changes, the immune system promotes the production of immune cells called eosinophils, which further ramp up inflammation and tissue damage. Previously, a 2022 study by the same team of investigators showed that this flood of eosinophils may help protect against parasite infections. However, in the inflammatory bowel disease model, this chain reaction exacerbated intestinal inflammation, weight loss and other symptoms like diarrhea.
Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University
Mohammad Arifuzzaman,Tae Hyung Won,Hiroshi Yano,Jazib Uddin,
Elizabeth R. Emanuel,Elin Hu,Wen Zhang,Ting-Ting Li,Wen-Bing Jin,Alex Grier,Sanchita Kashyap,Chun-Jun Guo,Frank C. Schroeder,David Artis
May, 2024
Inulin, a type of fiber found in certain plant-based foods and fiber supplements, causes inflammation in the gut and exacerbates inflammatory bowel disease in a preclinical model, according to a new study by Weill Cornell Medicine investigators.
The surprising findings could pave the way for therapeutic diets that may help ease symptoms and promote gut health.
He and his colleagues expected that inulin would also have protective effects in inflammatory bowel disease. But they found just the opposite.
Feeding inulin to mice in the context of a model of inflammatory bowel disease increased the production of certain bile acids by specific groups of gut bacteria. The increased bile acids boosted the production of an inflammatory protein called IL-5 by ILC2s. The ILC2s also failed to produce a tissue-protecting protein called amphiregulin. In response to these changes, the immune system promotes the production of immune cells called eosinophils, which further ramp up inflammation and tissue damage. Previously, a 2022 study by the same team of investigators showed that this flood of eosinophils may help protect against parasite infections. However, in the inflammatory bowel disease model, this chain reaction exacerbated intestinal inflammation, weight loss and other symptoms like diarrhea.
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