Is Entyvio Effective At Treating Crohn's Flares?

[Crohn2357]

Is it effective at treating Crohn's flare-ups? I know it has been found to be effective for UC flare-ups, what about Crohn's?

From what I have read and from my own experience with it, I find its effectiveness for treating moderate to severe Crohn's questionable

 

[crohnsinct]

From everything I have read, observed and been told by our GI it is about 37% effective with Crohn's and most effective treating Crohn's in the colon. It takes a LONG time to become effective. There is a chance those numbers are low because many people abandon treatment before it is able to fully kick in. It took my nephew 6 months for Entyvio to start working. He had failed all other meds and next step was surgery so he was willing to wait and luckily it worked out for him.

My daughter is in her 10th week and so far has ben admitted 4 times for the same flare so it isn't touching her colonic disease but we are still hoping.

 

[Crohn2357]

Crohnsinct, thank you for sharing. I have also read numerous times that entyvio can take a long time to work, and the patients should wait for six months before deciding it doesn’t work. I hope it will work for your daughter too.

 

[Crohn2357]

https://crohnsforum.com/threads/ved...n-in-some-patients-with-crohns-disease.85221/

 

[crohnsinct]

Yeah I saw that also. Thats the first time I saw a statistic so low. My daughter was moved up in dose to 600mg every 4 weeks as her trough levels were 11 and the theory is you need a trough of at least 20. There is a clinical trial going on now to test the effectiveness of the 600mg dosing every 4 and every 8 weeks so maybe Crohn's patients just need higher dosing?

She had her first 600mg dose on July 11th and it seems to be keeping her out of the hospital but she is still on 25mgs of prednisone and still has frequency, urgency, some liquid BM's and is still seeing some blood so definitely not in remission yet. It has been 15 weeks since starting Entyvio.

How are you doing?

 

[Crohn2357]

I think anti-tnfs and ustekinumab are much more preferable drugs than entyvio for Crohn's disease. Adding thiopurines (imuran or 6 mp) to the biologic therapy might make a positive difference. That's what I have been doing.

kiny's writings in that thread, as well as the data from the clinical studies on Entyvio for Crohn's patients are compelling.

 

[novax67]

I had a few good years on remicade before it stopped working and then failed on Stelara before GI put me onto Entyvio. About one year on it and I started to notice improvement after about 6 months. Recent colonoscopy showed 91% improvement - inflammation almost completely cleared up and feeling much better day-to-day. My Crohn's is isolated to a small area in the ileum so it can work on Crohns higher in the digestive track but it did take me awhile to feel like it started to work.

 

[GI Jane]

I am on my 8th month of Vedolizumab with inflammatory markers down but no end in site on diarrhea. Remicade became allergic too and this seems to be my last hope until something new comes out....I miss Asacol....was so upsetting when taken off market....it was my wonder drug....tried the mesalamine and gave me such bad migraines thought my head would explode.....sigh.....hoping you're right on it just taking longer to work.

 

[crohnsinct]

Has your doctor looked into SIBO? My daughter has horrible colonic disease and when her inflammatory markers were finally down she still had diarrhea and they said it was SIBO and treated her for that.

 

[GI Jane]

Has your doctor looked into SIBO? My daughter has horrible colonic disease and when her inflammatory markers were finally down she still had diarrhea and they said it was SIBO and treated her for that.

No had to look this one up but I sure have these symptoms. Meet with doc on Wed so will ask. Got blood work and we shall see from there thanks.