Not sure how LDN really works but I was interested in it, not to take it but to know what it is. Would love for someone to explain it who knows more about it.
Your body has opoid receptors in your brain and gut, they've known this since forever since when you take opiates, narcotics, they interact with the opoid receptors and people get high.
But they knew the opoid receptors weren't there by accident, they weren't there for recreational drugs, they were there for another reason.....if your body has receptors for narcotics, it's not unreasonable to think that your body actually makes it's own opiates....not too long ago they found out why, your body does have it's own type of opiates, named endorphins.
Endorphins can be measured in animals when they are under extreme stress, for example when they get into a fight with another animal, the body of the animal will raise endorphins that act on the opoid receptors, it will lower the amount of pain it feels from wounds, and it interacts with the immune system because those cuts can infect the animal.
LDN blocks those opoid receptors only for a few hours, and in doing that it raises endorphins once the LDN wears off, that's why it needs to be used at a very low dose, since if you give too high a dose you would just block the opoid receptors for too long.
Also, the reason they tell peple to take it right before bed I believe, because endorphins are very active in that specific period, and if you block opoid receptors at a very active endorphin level, you will greatly increase endorphins for the rest of the day, it's that short blockade of opoid receptors that raises endorphins for the rest of the day. For a few hours at night the body is being blocked from utilising endorphins, as a countermeasure it raises endorphins, once LDN wears off after an hour or two, you now have many many more endorphins in your body than before. If you took LDN all day it wouldn't work since you would have a constant blockade of opoid receptors, if you took too high a dos it wouldn't work either because you would simply block too many receptors and the body wouldn't raise endorphins. That's why LDN is a very low dose and is taken at a time where endorphins are very active, to maximize a raise in endorphins for the rest of the day.
How it works for crohn's disease I don't understand. It interacts with the immune system and the fact we have so many opoid receptors not only in the brain but also in the gut, is why I think it works, it's also I think why people say marijuana works for CD.
