Hello, we have lots of experience with remicade and changes of dosing. When my son started, he could not make it to 8 weeks - this was right at the start - he had a reloading dose and was increased to 5 mg every 4 weeks. He had almost zero levels of remicade and a flare after his first loading doses were completed. He did so well for a few weeks and then would drop off quickly. The increase to 5 mg/4 weeks still wasn't enough. He was good for 3 weeks and then started showing symptoms again - this went on for a few months and then he flared badly again. Another blood test - almost zero levels (this was about 6 months in now. GI increased again- this time 10 mg/4 weeks. This seem to be what worked. He had another blood test, 6 months after that, and was at level 10 which was a great level. A year later, another levels test revealed Remicade levels at 28 - very high - and now he is back down to 5 mg/4 weeks, and will have another blood test in the near future to see if it might change again. He has been doing really well once the dose was increased and has been on Remicade since Sep 2018.