Low Secretory IgA- What does it mean?

[Farmwife]

Grace's stool sample came back and
the note to our Doctor
stated that her Secretory IgA was low.

What does that mean?:shifty:

Thanks a bunch for the help.

 

[my little penguin]

http://intestinalbarriertest.com/pdf/Secretory_IgA_interpretation.pdf

An imbalance of protective SIgA can result in a compromised mucosal immunity and eventual gastrointestinal, immunological and neurological disorders.
A deficiency of SIgA may be an indication of chronic stress, adrenal insufficiencies, bacterial colonization on molar surfaces, recurrent tonsillitis, adenoid hyperplasia, cutaneous candidiasis, intestinal barrier dysfunction, nutritional deficiencies, recurrent herpes infection, celiac, crohn’s or ulcerative colitis. Patients presenting with low levels of SIgA are at greater risk of gastrointestinal infections, dysbiosis and autoimmune disorders. Such a patient may have increased IgG responses to multiple foods, or may be asympomatic.
Known Causes of Low SIgA:
Anti-inflammatory drugs

Cyclosporine Fenclofenac Gold
Hydantoin Sodium valproate Sulfasalazine

 

[my little penguin]

http://www.immunedisease.com/about-pi/types-of-pi/selective-iga-deficiency.html
This may also help

 

[my little penguin]

Although Selective IgA Deficiency is usually
one of the milder forms of immunodeficiency,
it may result in severe disease in some people. Therefore, it is difficult to predict the long-term outcome in a given patient with Selective IgA Deficiency. In general, the prognosis in Selective IgA Deficiency depends on the prognosis of the associated diseases. It is important for physicians to continually assess and reevaluate patients
with Selective IgA Deficiency for the existence of
associated diseases and the development of more extensive immunodeficiency. For example, rarely, IgA deficiency will progress to become Common Variable Immunodeficiency with its deficiencies of IgG and/or IgM. The physician should be notified of anything unusual, especially fever, productive cough, skin rash or sore joints. The key to a good prognosis is adequate communication with the physician and the initiation of therapy as soon as disease processes are recognized.

From link above

 

[my little penguin]

Side most kids with allergies/asthma have a low sig igA
Mine does I believe.

 

[Farmwife]

Thanks my little penguin.:heart:
You've made my Christmas list.

Is there different IgA's?

 

[my little penguin]

Selective deficiency of IgA is the most common immune deficiency disorder. Persons with this disorder have low or absent levels of a blood protein called immunoglobulin A.
Causes, incidence, and risk factors
IgA deficiency is usually inherited, which means it is passed down through families. However, cases of drug-induced IgA deficiency have been reported.
It may be inherited as an autosomal dominant or autosomal recessive trait. It is found in approximately 1 in 700 individuals of European origin. It is less common in people of other ethnicities.
See also: Celiac disease - sprue
Symptoms
Many people with selective IgA deficiency have no symptoms.
Symptoms include frequent episodes of:
Bronchitis

Chronic diarrhea
Conjunctivitis (eye infection)
Gastrointestinal inflammation including ulcerative colitis, Crohn's disease, and a sprue-like illness
Mouth infection
Otitis media (middle ear infection)
Pneumonia

Sinusitis

Skin infections
Upper respiratory tract infections
Other symptoms include:
Bronchiectasis (a disease in which the small air sacs in the lungs become damaged and enlarge)
Unexplained asthma
Signs and tests
There may be a family history of IgA deficiency. Tests that may be done include:
IgA
IgG
IgG subclass measurements
IgM
Quantitative immunoglobulins

Serum immunoelectrophoresis

Treatment
No specific treatment is available. Some people gradually develop normal levels of IgA without treatment.

From:

http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002447/


There is only one type of IgA.
It is called secretory since it is what protects your mucosal membrane including the gut .

 

[Farmwife]

my little penguin,
This is only ONE test. Might this change?
Watching my bubble fall apart.
DustyKat a smiley in a bubble if you have one would be great.

Will more be done to test or once IgA low it stays there. Her number was in the 30's

 

[my little penguin]

Low serum IgA levels in children aged 6 months to 4 years should be confirmed to be persistently low at age 4 years before making a lifetime diagnosis of IgAD. Some children with a low level when aged 6 months to 4 years progress to common variable immunodeficiency (CVID), whereas others completely normalize.

From :
http://emedicine.medscape.com/article/136580-workup#1

She is four so you would need to repeat the test.
Plus not sure of the unit on 30??
Below 5 is considered IgA deficient . Otherwise low is just partial defienct.
Most likely more blood tests.

 

[Farmwife]

Well good, maybe my bubble will still be intact. :thumleft:

 

[Jenn]

Fascinating! Alex has had nearly all these symptoms. We tested his IgA recently and it's on the high end of normal, we were in fact concerned about Celiac too and just ruled it out. I wonder if his wasn't deficient as a baby, we never tested then. huh.

 

[Farmwife]

Thanks Jenn,
I know every strange thing out their sounds familiar now!

 

[Tesscorm]

Plus not sure of the unit on 30??
Below 5 is considered IgA deficient .

Just FYI... not sure if it's related but Stephen's blood tests have shown results for

ASCA-IgA and IgA

ASCA-IgA normal range (from our lab) is <20

IgA normal range is 0.5-3.5 (as is the case with some other tests, the 0.5-3.5 may convert to 5-35)

(I don't know what the difference is between ASCA-IgA and IgA)