Lymphonodular hyperplasia

[asadmom]

Has anyone gotten "lymphonodular hyperplasia" noted in their child's pill cam report? My son's endoscopy and colonoscopy including biopsies came back normal just two months ago. This week's pill cam noted lymphonodular hyperplasia in the terminal ileum so it seems to me that he got it just from the past 2 months. The doctor said it's not a lot and it's normal for kids at his age to get them. This is the first time we encountered this term. Asking for opinions.

 

[my little penguin]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511677/Large percentage of kids with food sensitivity have it

 

[asadmom]

Does it ever go away if the trigger food is removed? My son has never had this in any of his reports before.

 

[my little penguin]

Symptoms of all patients (n = 25) including rectal bleeding in 19, chronic abdominal pain in 3, chronic diarrhea in 2, and chronic constipation in 1 improved with the elimination diet.

From paper

 

[my little penguin]

LNH is a common finding during pediatric colonoscopy, but its clinical significance and etiologic factors are unclear. Previous studies have defined the association of LNH with food allergy, infections, and immunodeficiency syndromes in adults [3, 4, 5, 6]. Additionally, it has been shown to have an association with connective tissue diseases, inflammatory bowel disease (IBD), juvenile idiopathic arthritis, lymphoma, and refractory constipation [3]. Interestingly, an association was shown between LNH and autism due to chronic constipation [7]. It can also be seen in normal individuals without any symptoms or may be related to nonspecific chronic abdominal symptoms [3, 8, 9].

From paper

 

[asadmom]

Not symptoms but the actual plasia. I wonder if it goes away on its own.

 

[Stressedmom]

My son had/ has it. It’s a common finding in children and teens. The doctor at time said it indicated a strong immune response to something.

 

[Andersen007]

I had it 3 years ago during ileocolonoscopy. This was 1.5 years before I got diagnosed with Crohns. The doc just said its fairly common in young adults and did not consider it a significant finding at all, the doc doing the exam actually didnt even biopsy it. I do have many food sensitivities incl celiac disease for 10+ years. I do wonder sometimes if they would have biopsied it, they would have seen something indicating Crohns much sooner, as I have ileal CD. On my ileocolonoscopy 1.5 years later they no longer noted this finding, I just had 2 small apthous ulcers leading to my eventual diagnosis.

 

[Stressedmom]

I wonder if it's so typical to see they don't always note it? It was noted in my son's colonoscopy, but not in pillcam, but I think pillcam looked more at small intestine. I have to look back, but I don't think they noted it at the terminal ilium in pillcam. It's a common finding in GI kids, not sure if they have looked at kids with no GI issues, since there would be ethical issues with giving them scopes and pillcams without symptoms. You don't hear about it much in asymptomatic adults getting colonoscopies and I've never heard an adult with polyps or even colon cancer mention it. It's interesting that Andersen had it noted, but maybe it's still not uncommon in one's 20s.