Medscape vitamin d and Ibd

[my little penguin]

http://www.medscape.com/viewarticle/818324?src=wnl_edit_tpal&uac=185734DZ

Limited data also suggest an association between low vitamin D levels and increased disease activity, particularly in CD. In a large cohort, vitamin D deficiency (<20 ng/mL) was associated with increased risk of surgery (OR 1.8, 95% CI 1.2–2.5) in CD and hospitalisations in both CD (OR 2.1, 95% CI 1.6–2.7) and UC (OR 2.3, 95% CI 1.7–3.1). A single randomised controlled trial demonstrated that vitamin D supplementation may be associated with reduced frequency of relapses in patients with CD compared with placebo (13% vs. 29%, P = 0.06).

Things that make you go hmmmmm.,.

 

[DustyKat]

That’s the team I’m on! :lol:

Nothing less than 100 nmol/l with an optimum level of 125 nmol/l. I like to think that it is another piece of the puzzle to keeping them in remission. Thanks for posting mlp.

Dusty. xxx

 

[kiny]

Yes, it's partly restoring autophagy function in the macrophage. Crohn's disease patients have autophagy defects, ATG16L1 (ATG =autophagy).

In theory it would work best in crohn's disease patients with NOD2, ATG16L1, IRGM or VDR gene mutation. The theory is that it restores the immunodeficiency caused by defective NOD2 signaling and the autophagy step itself. Genetic defects. Optimum Vitamin D levels would restore some of those defects, or at the very least allow the macrophage to run optimally to clear bacteria.

very good explanation: http://www.expert-reviews.com/doi/pdf/10.1586/eci.10.31

As you can see here, it is partially restoring macrophage function, which allows it to kill crohn's disease E Coli.

The first studies assumed it would partially restore macrophage functions, the newest studies are showing that is exactly what it is doing.