Microbiome Breakthrough: New Crohn's Treatment Unveiled

[J100]

I came across this article. Research done by

https://www.miragenews.com/microbiome-breakthrough-new-crohns-treatment-1406399/​

@kiny , @my little penguin , @Scipio -your thoughts and comments

 

[my little penguin]

My two cents
You need to wait and see
Most mice models for various treatments don’t have large success rates in humans for Crohn’s disease
Fecal transplant doesn’t have high success rates at all for crohns
Een does have success in certain circumstances especially little kids since parents ensure compliance .
Een has its own risks though .
It would be nice if it were true but
Early stages
Needs more time /experiments especially on the fecal transplant side .
Een is a good treatment plan in the short term for kids and adults until you get a maintenance plan that works for you

 

[Scipio]

I agree with MLP. The mouse models for human IBD are pretty lousy. Something that works well in mice may or may not have much to say about human disease.

What they've got here is perhaps enough data to justify a small human safety trial. If it looks safe for humans then move on to an efficacy trial, but I'm not getting excited about any new therapy until I see the human clinical trial data.

 

[J100]

@my little penguin & @Scipio - I agree that models which work in mice may not work at all in humans. However, if this is successful then it will be great though it may take years for any such research to be fruitful.