In november 2012 i've been diagnosed with inflammatory bowel disease, Crohn's disease suspected. I did have some pain in my intestines now and then and suffered a few food intolerances but i was actually doing fine until the gastroenterologist prescribed me ciprofloxacin and flagyl for a suspected infection because the pathologist found Aeromonas veronii in a biopsy tissue from the ileum.
I later found out this "Pathogen" is usually transient and doesn't cause inflammation as found during the colonoscopy.
After a few days i got immensely sick and i wanted to quit the cipro but my GI told me to stay on it. 2 weeks later i was severely poisoned by this fluoroquinlone antibiotic (lookup fluoroquinlone toxicity) and ever since my health has been destroyed. Now i'm 80% bedbound, suffer from dysautonomia / POTS, bad neurocognitive inflammation and many food intolerances.
Since then i don't trust doctors anymore except my LLMD. I've had more success treating my IBD with diet and natural anti-inflammatories than any of these so called IBD-meds together.
My life has been destroyed by an incompetent gastroenterologist and a corrupt FDA which still allows fluoroquinlone antibiotics to be prescribed.
I can rant on forever about incompetent doctors but that's not why i started this thread. I'm hoping that maybe some of you recognize the pathology and colonoscopy findings posted below.
From the report it shows that the inflammation is non-specific, but that doesn't cut it for me.
Here we go.
Lab results have always been negative. Here are some results besides the basic stuff like liver values, routine chemistry etc.
p-ANCA/Anti-Myeloperoxidase (MPO)* negative
c-ANCA/Anti-Proteinase 3 (PR3)* negative
Saccharomyces cerevisiae Antibody (ASCA), IgG negative
Saccharomyces cerevisiae Antibody (ASCA), IgA negative
Proteinase 3 Antibody (cANCA) negative
Lactoferrin Antibody (pANCA) negative
Myeloperoxidase Antibody (pANCA) negative
Elastase Antibody (pANCA) negative
Cathepsin G Antibody (pANCA) negative
BPI Antibody (pANCA) negative
ANA negative
Anti-Gliadin IgA* negative
Anti-Gliadin IgG* negative
Anti-tissue Transglutaminase IgA* negative
Anti-tissue Transglutaminase IgG* negative
Stool calprotectin negative
Stool occult blood negative
Very low ESR and CRP
Neutrophil low percentage, but total count within range albeit low
Lymphocyte high percentage, but total count within range albeit high
WBC count hovers between 4000 and 5000
First colonoscopy with biopsies done on 21 november 2012.
Findings colonoscopy:
Terminal ileum: Difuse lymphois hyperplasia with mild erosive ileitis, biopsy was obtained.
Colon: Diffuse Mild colitis - proctitis with skip pattern and scattered apthus ulcers from rectum through distal
transverse colon, random biopsy were obtained, otherwise unremarkable
Endoscopic diagnosis:
Left side colitis - proctits cause?
Pathology report:
A) SCO four pieces of pale brown tissue, measuring 0,2cm in each
B) SCO two pieces of pale brown tissue, measuring 0,2cm in each
C) SCO three pieces of pale brown tissue, ranging from 0.1 to 0.2cm in GD
D) SCO two pieces of pale brown tissue, measuring 0.1 and 0.2cm in GD
E) SCO four pieces of pale brown tissue, ranging from 0.1 to 0.2cm in GD
Microscopic description:
Section A reveals four fragments of small bowel mucosa without flattening of villi.
There are lymphocytoplasmacytic and few eosinophilic infiltrate in the surface epithelium, lamina propria, and
among hyperplastic crypts together with scattered lymphoid aggregates. It is also seen
diffuse congestion in the lamina propria. Organism or granuloma is not identified on the plane of examination.Figure 1
Section B displays two pieces of colonic mucosa with lymphocytoplasmacytic and small numbers of neutrophilic infiltrate
in mild edematous lamina propria as well as focal cryptitis. Glandular architecture is preserved.
There is focal lymphoid aggregation. Organis is not observed.Figure 2 Section C displays three pieces of colonic mucosa with focal hyperplasia. There is lymphoplasmacytic and small numbers
of neutrophilic infiltrate in mild edematous lamina propria as well as focal cryptitis.
Glandular architecture is preserved. THere is focal lympoid aggregation. Organism is not observed.
Section D displays two fragments of polypod lesion comprimising hyperplastic glands. They are enclosed with
mixed inflammatory cells and congested vessels. There is no evidence support malignancy on the plane of examination.
Section E displays four pieces of colonic mucosa with focal hyperplasia. There is lymphoplasmacytic and small
numbers of neutrophilic infiltrate in mild edematous lamina propria as well as focal cryptitis.
Glandular architecture is preserved. There is focal lymphoid aggregation. Organism is not found.
Final diagnosis pathology:
SMall bowel biopsy (ileum): Mild non specific ileitis
No organism or granuloma seen
Colonic biopsy (splenic flexure): Mild acute nonspecific colitis
No organism seen
Colonic biopsy (siggmoid): Mild acute nonspecific colitis
No organism seen
Colonic biopsy (rectum): Hyperplastic polyp
Colonic biopsy (unstated site): Mild acute nonspecific colitis
No organism seen
Tissue biopsy from ileal region:
Moderate Growth Aeromonas veronii
Pathology microscopic image 21 november 2012
http://i68.tinypic.com/312wbgx.jpg
Colonoscopy images 21 november 2012
http://i66.tinypic.com/2airp6q.jpg
http://i64.tinypic.com/2ebfj0h.jpg
Second colonoscopy + capsule camera study + biopsies done on 23 july 2013.
Pathology report:
A) SCO four pieces of pale brown tissue, ranging from 0.1 to 0.2 cm in GD
B) SCO two pieces of pale brown tissue, measuring 0.1 and 0.2 cm in GD
C) SCO fthree pieces of pale brown tissue, measuring 0.2cm in each.
D) SCO a piece of pale brown tissue, measuring 0.3cm in GD.
E) SCO two pieces of pale brown tissue, measuring 0.1cm in each.
Miscroscopic description:
Section A reveals four fragments of small bowel mucosa without flattening of villi. There are lymphoplasmacytic and few eosinophilic infiltrate in the surface
epitheleum, lamina propria, and among hyperplastic crypts together with
scattered lymphoid aggregates. It is also seen diffuse congestion in the lamina propria. Organism is not identified on the plane of examination. Figure 1
Section B displays two pieces of colonic mucosa with lymphoplasmacytic and small numbers of neutrophilic
infiltrate in mild edematous lamina propria as well as focal cryptitis. Glandular architecture is preserved. There is focal lymphoid aggregation.
Organism is not observed. Figure 2.
Section C displays three pieces of colonic mucosa with focal hyperplasia of the surface epitheleum.
There is lymphoplasmacytic and small numbers of neutrophilic infiltrate in mild edematous lamina propria as well as focal cryptitis.
Glandular architecture is preserved. There is scattered subepithelial hemorrhage. Organism is not observed.
Section D displays two pieces of colonic mucosa with focal hyperplasia of the surface epitheleum. There is lymphoplasmacytic and small numbers of neutrophilic infiltrate
in mild edematous lamina propria as well as focal cryptitis. Glandular acrhitecture is preserved. There is scattered subepithelial hemorrhage. Organism is not observed.
Section E displays two fragments of polypoid lesion comprising hyperplastic glands. They are enclosed with
mixed inflammatory cells and congested vessels. There is no evidence support malignancy on the plane of examination.
Final diagnosis:
Small bowel biopsy (ileum): Mild non specific ileitis
Organism not seen
Colonic biopsy (cecum and ascending colon): Mild acute nonspecific colitis
No organism seen
Colonic biopsy (Hepatic flexure and transverse colon): Mild acute nonspecific colitis. No organism seen.
Colonic biopsy (descending colon and sigmoid): Mild acute nonspecific colitis. No organism or chronicity seen
Colonic biopsy (rectum): Hyperplastic polyp.
Pathology microscopic image 23 july 2013
Capsule camera 23 july 2013 findings
Gastric passage time: 0h 54m.
Small bowel pasage time: 5h 49m.
Procedure findings:
- Mild hiatal hernia
- Mild gastritis
- Normal duodenal and proximal jejenum mucosa up to mid jejenum
- There are multiple discrete erosions and ulcers from mid jejenum through terminal ileum, more ulcers
were detected at mid jejenum through proximal ileum with skip pattern. However, majority of extensive erosive lesions
were noted at ileim from proximal ileum through mid ileum with skip pattern. At terminal ileum, revealed multiple
lymphoids hyperplasia with very few area of erosion, biopsy stima was noted at terminal ileum, otherwise unremarkable.
Summary & recommendation:
Hiatal hernia
- Diffuse erosive jejunitis and ileitis, Crohn's disease is considered.
Capsule camera images 23 july 2013
CT scan of whole abdomen with contrast July 2013:
Increased number of ileal folds(Jejunization of ileum) of some ileal loops at RLQ and in Rt pelvic cavity,suspicious of celiac disease.
I later found out this "Pathogen" is usually transient and doesn't cause inflammation as found during the colonoscopy.
After a few days i got immensely sick and i wanted to quit the cipro but my GI told me to stay on it. 2 weeks later i was severely poisoned by this fluoroquinlone antibiotic (lookup fluoroquinlone toxicity) and ever since my health has been destroyed. Now i'm 80% bedbound, suffer from dysautonomia / POTS, bad neurocognitive inflammation and many food intolerances.
Since then i don't trust doctors anymore except my LLMD. I've had more success treating my IBD with diet and natural anti-inflammatories than any of these so called IBD-meds together.
My life has been destroyed by an incompetent gastroenterologist and a corrupt FDA which still allows fluoroquinlone antibiotics to be prescribed.
I can rant on forever about incompetent doctors but that's not why i started this thread. I'm hoping that maybe some of you recognize the pathology and colonoscopy findings posted below.
From the report it shows that the inflammation is non-specific, but that doesn't cut it for me.
Here we go.
Lab results have always been negative. Here are some results besides the basic stuff like liver values, routine chemistry etc.
p-ANCA/Anti-Myeloperoxidase (MPO)* negative
c-ANCA/Anti-Proteinase 3 (PR3)* negative
Saccharomyces cerevisiae Antibody (ASCA), IgG negative
Saccharomyces cerevisiae Antibody (ASCA), IgA negative
Proteinase 3 Antibody (cANCA) negative
Lactoferrin Antibody (pANCA) negative
Myeloperoxidase Antibody (pANCA) negative
Elastase Antibody (pANCA) negative
Cathepsin G Antibody (pANCA) negative
BPI Antibody (pANCA) negative
ANA negative
Anti-Gliadin IgA* negative
Anti-Gliadin IgG* negative
Anti-tissue Transglutaminase IgA* negative
Anti-tissue Transglutaminase IgG* negative
Stool calprotectin negative
Stool occult blood negative
Very low ESR and CRP
Neutrophil low percentage, but total count within range albeit low
Lymphocyte high percentage, but total count within range albeit high
WBC count hovers between 4000 and 5000
First colonoscopy with biopsies done on 21 november 2012.
Findings colonoscopy:
Terminal ileum: Difuse lymphois hyperplasia with mild erosive ileitis, biopsy was obtained.
Colon: Diffuse Mild colitis - proctitis with skip pattern and scattered apthus ulcers from rectum through distal
transverse colon, random biopsy were obtained, otherwise unremarkable
Endoscopic diagnosis:
Left side colitis - proctits cause?
Pathology report:
A) SCO four pieces of pale brown tissue, measuring 0,2cm in each
B) SCO two pieces of pale brown tissue, measuring 0,2cm in each
C) SCO three pieces of pale brown tissue, ranging from 0.1 to 0.2cm in GD
D) SCO two pieces of pale brown tissue, measuring 0.1 and 0.2cm in GD
E) SCO four pieces of pale brown tissue, ranging from 0.1 to 0.2cm in GD
Microscopic description:
Section A reveals four fragments of small bowel mucosa without flattening of villi.
There are lymphocytoplasmacytic and few eosinophilic infiltrate in the surface epithelium, lamina propria, and
among hyperplastic crypts together with scattered lymphoid aggregates. It is also seen
diffuse congestion in the lamina propria. Organism or granuloma is not identified on the plane of examination.Figure 1
Section B displays two pieces of colonic mucosa with lymphocytoplasmacytic and small numbers of neutrophilic infiltrate
in mild edematous lamina propria as well as focal cryptitis. Glandular architecture is preserved.
There is focal lymphoid aggregation. Organis is not observed.Figure 2 Section C displays three pieces of colonic mucosa with focal hyperplasia. There is lymphoplasmacytic and small numbers
of neutrophilic infiltrate in mild edematous lamina propria as well as focal cryptitis.
Glandular architecture is preserved. THere is focal lympoid aggregation. Organism is not observed.
Section D displays two fragments of polypod lesion comprimising hyperplastic glands. They are enclosed with
mixed inflammatory cells and congested vessels. There is no evidence support malignancy on the plane of examination.
Section E displays four pieces of colonic mucosa with focal hyperplasia. There is lymphoplasmacytic and small
numbers of neutrophilic infiltrate in mild edematous lamina propria as well as focal cryptitis.
Glandular architecture is preserved. There is focal lymphoid aggregation. Organism is not found.
Final diagnosis pathology:
SMall bowel biopsy (ileum): Mild non specific ileitis
No organism or granuloma seen
Colonic biopsy (splenic flexure): Mild acute nonspecific colitis
No organism seen
Colonic biopsy (siggmoid): Mild acute nonspecific colitis
No organism seen
Colonic biopsy (rectum): Hyperplastic polyp
Colonic biopsy (unstated site): Mild acute nonspecific colitis
No organism seen
Tissue biopsy from ileal region:
Moderate Growth Aeromonas veronii
Pathology microscopic image 21 november 2012
http://i68.tinypic.com/312wbgx.jpg
Colonoscopy images 21 november 2012
http://i66.tinypic.com/2airp6q.jpg
http://i64.tinypic.com/2ebfj0h.jpg
Second colonoscopy + capsule camera study + biopsies done on 23 july 2013.
Pathology report:
A) SCO four pieces of pale brown tissue, ranging from 0.1 to 0.2 cm in GD
B) SCO two pieces of pale brown tissue, measuring 0.1 and 0.2 cm in GD
C) SCO fthree pieces of pale brown tissue, measuring 0.2cm in each.
D) SCO a piece of pale brown tissue, measuring 0.3cm in GD.
E) SCO two pieces of pale brown tissue, measuring 0.1cm in each.
Miscroscopic description:
Section A reveals four fragments of small bowel mucosa without flattening of villi. There are lymphoplasmacytic and few eosinophilic infiltrate in the surface
epitheleum, lamina propria, and among hyperplastic crypts together with
scattered lymphoid aggregates. It is also seen diffuse congestion in the lamina propria. Organism is not identified on the plane of examination. Figure 1
Section B displays two pieces of colonic mucosa with lymphoplasmacytic and small numbers of neutrophilic
infiltrate in mild edematous lamina propria as well as focal cryptitis. Glandular architecture is preserved. There is focal lymphoid aggregation.
Organism is not observed. Figure 2.
Section C displays three pieces of colonic mucosa with focal hyperplasia of the surface epitheleum.
There is lymphoplasmacytic and small numbers of neutrophilic infiltrate in mild edematous lamina propria as well as focal cryptitis.
Glandular architecture is preserved. There is scattered subepithelial hemorrhage. Organism is not observed.
Section D displays two pieces of colonic mucosa with focal hyperplasia of the surface epitheleum. There is lymphoplasmacytic and small numbers of neutrophilic infiltrate
in mild edematous lamina propria as well as focal cryptitis. Glandular acrhitecture is preserved. There is scattered subepithelial hemorrhage. Organism is not observed.
Section E displays two fragments of polypoid lesion comprising hyperplastic glands. They are enclosed with
mixed inflammatory cells and congested vessels. There is no evidence support malignancy on the plane of examination.
Final diagnosis:
Small bowel biopsy (ileum): Mild non specific ileitis
Organism not seen
Colonic biopsy (cecum and ascending colon): Mild acute nonspecific colitis
No organism seen
Colonic biopsy (Hepatic flexure and transverse colon): Mild acute nonspecific colitis. No organism seen.
Colonic biopsy (descending colon and sigmoid): Mild acute nonspecific colitis. No organism or chronicity seen
Colonic biopsy (rectum): Hyperplastic polyp.
Pathology microscopic image 23 july 2013
Capsule camera 23 july 2013 findings
Gastric passage time: 0h 54m.
Small bowel pasage time: 5h 49m.
Procedure findings:
- Mild hiatal hernia
- Mild gastritis
- Normal duodenal and proximal jejenum mucosa up to mid jejenum
- There are multiple discrete erosions and ulcers from mid jejenum through terminal ileum, more ulcers
were detected at mid jejenum through proximal ileum with skip pattern. However, majority of extensive erosive lesions
were noted at ileim from proximal ileum through mid ileum with skip pattern. At terminal ileum, revealed multiple
lymphoids hyperplasia with very few area of erosion, biopsy stima was noted at terminal ileum, otherwise unremarkable.
Summary & recommendation:
Hiatal hernia
- Diffuse erosive jejunitis and ileitis, Crohn's disease is considered.
Capsule camera images 23 july 2013
CT scan of whole abdomen with contrast July 2013:
Increased number of ileal folds(Jejunization of ileum) of some ileal loops at RLQ and in Rt pelvic cavity,suspicious of celiac disease.
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