Novel AIDs Anti-Vaccine; alternate tack for Crohn's?

[xeridea]

Unrelated to CD, but this "anti-vaccine" approach may open up some new research and treatment approaches for Crohn's.

I say this because the paper talks about CD4 and CD8 T-Cells which I've read about in other papers as being involved in body's immune response in Crohn's. I don't recall the specifics so I have to go back and re-read some of those papers to see if I can pull together any correlations.

Here's an excerpt on how this works: "HIV ‘boots’ itself into the body precisely by getting the immune system to react to it and thereby make lots of new activated CD4 cells to infect: if the CD4 cells don’t recognize it as foreign, no infection gets established. What these cells appear to do is to suppress the response in CD4 cells to HIV by inducing the CD4 cells to change the MHC molecules on their surface. The job of these molecules is to detect foreign proteins."

So I posit that a similar approach may be used to desensitize body's response to commensal bacteria or whatever protein it's reacting to with its runaway response in the gut.

 

[Gail Jothen]

more research is needed on IBD! There has got to be some way to help with the many autoimmune diseases!

 

[nogutsnoglory]

I saw this news and certainly thought of it. The more research and trials done on autoimmune diseases the more progress we will make. They often have overlaps and who knows where a cure may lie. Many things were found out by chance and diseases helped by drugs designed for other purposes like most of the current crohns drugs.