When I'm on prednisone, I'm tapered off while taking 9 tablets of pentasa daily. I think if you are experiencing pain while being tapered off of prednisone, and while using pentasa as well, you should let the doc know. Pentasa, for me anyways, would never do the trick on its own if I had already been tapered off the prednisone. If you are not feeling better, and you are already tapered off the prednisone, I would guess that you are probably still flaring, and that the pentasa won't help much right now. It's for mild disease, and in my experience, never helped me. I was put on imuran, and now I am waiting for remicade.