Senolytics reduce gut inflammation in mice

[waywardcaptain]

https://www.lifespan.io/news/senolytics-reduce-gut-inflammation-in-mice/

Though I do intend to try the dasatinib-quercetin combo, fisetin has also shown some senolytic properties, as well as temporarily downregulating TNF-alpha and IL-6, iirc. I've been doing a monthly 20 mg/kg round of this supplement (same dose as the Mayo Clinic frailty trial) and had my first clear scope in at least a decade a little over a year ago, so I'm hoping it's proving as beneficial as it feels. (Not magic, but even a bit less miserable is something.)

 

[lukesjr]

what brand quercetin are you using? Where did you find the 20 mg/kg?

 

[lukesjr]

Are you taking fisetin at 20mg/kg?

 

[CatLover63]

Mice like cheese, so do humans, obviously the science is clear.

 

[waywardcaptain]

what brand quercetin are you using? Where did you find the 20 mg/kg?

I currently take fisetin, I haven't tried quercetin yet. I was planning to use the guide from here when I do want to try one round of the dasatinib-quercetin combo, as they are significantly more effective together than separate: https://www.fightaging.org/self-experimentation/

 

[waywardcaptain]

Are you taking fisetin at 20mg/kg?

Correct, once a month 20 mg/kg of fisetin. Worst it's ever given me is a little bit of a stomach ache and transient constipation.

 

[waywardcaptain]

Mice like cheese, so do humans, obviously the science is clear.

Hahaha admittedly, the translation rate is not great, though in the case of dasatinib and quercetin, it's also been confirmed to reduce senescent cells in humans, which are a significant cause of constant low-grade inflammation: https://www.fightaging.org/archives...-burden-of-senescent-cells-in-human-patients/

 

[CatLover63]

Hahaha admittedly, the translation rate is not great, though in the case of dasatinib and quercetin, it's also been confirmed to reduce senescent cells in humans, which are a significant cause of constant low-grade inflammation: https://www.fightaging.org/archives...-burden-of-senescent-cells-in-human-patients/

Try explaining that to a GP in a busy practice in London. You get 10 minutes after a 2 hour wait and told to buy Windeeze for flatulence for £5.00 a packet.

 

[lukesjr]

Correct, once a month 20 mg/kg of fisetin. Worst it's ever given me is a little bit of a stomach ache and transient constipation.

Sorry to bother, but are you take 20 mg/kg for just 1 day a month? Also, what brand are you using. Thanks.

 

[waywardcaptain]

Sorry to bother, but are you take 20 mg/kg for just 1 day a month? Also, what brand are you using. Thanks.

No problem at all! I initially did 2 days in a row for 2 months in a row, and then I've done 1 day a month since. I take the Rejuvenation Therapeutics one, since the only filler they use is potato starch. https://rejuvenation-therapeutics.c...lammatory-gluten-free-100mg-30-vegan-capsules [ingredients list: fisetin, organic potato starch, hypromellose (capsule)]

 

[lukesjr]

Thanks. Best of luck to you in the new year

 

[waywardcaptain]

Thanks. Best of luck to you in the new year

Thanks! Same goes for you as well!

 

[lukesjr]

Hey wayward, any reason why you don't just take the 100mg per day instead of going down the 20mg/kg route? I know the study did 20mg/kg.

 

[waywardcaptain]

Hey wayward, any reason why you don't just take the 100mg per day instead of going down the 20mg/kg route? I know the study did 20mg/kg.

I only found out about the evidence for that a couple of days ago tbh. lol Haven't decided yet whether I want to switch over. It's probably not for me, since I'm prone to gastritis and my stomach doesn't like even these supplements sometimes