Small Intestine Permeability test

[crohnsinct]

Anyone here have it done? Some interesting stuff surrounding this test. T had one done three years ago when her sister was dx'd and she just had another one done 4 weeks after starting treatment.

My big dilema is this. The mannitol and lactulose were given to us mid January and no one told us to refrigerate them. We did the test last night. I mixed the stuff and she drank it. Poor kid has drank so much crappy stuff the past month I think she is ready for Fear Factor! Anyway, this a.m. I realized that one of them had an expiration date of December 2014:ack: and that they were both supposed to have been refrigerated all this time. Oops!

When I brought the sample in this a.m. I explained what had happened and asked if we should repeat the test because I may have screwed up the results with my mistake. The nurse was more concerned with T's health...ummm oh yeah...better call the school and make sure she is still vertical. She wasn't sure about the non refrigerated mannitol and lactulose affecting results and didn't seem like she was going to check into it either. Not that it will affect much of what we are doing but for research purposes I would like them to have the best info.

Anyway, in case you are interested there is some stuff on this site about SIP.

http://the-medical-dictionary.com/crohn_s_disease_article_2.htm

 

[Lindseyw4]

Never had this done but interesting read!

 

[my little penguin]

Yikes
Always check the label
Then check it again

 

[Sascot]

Hope she doesn't have any issues with the expired meds - oops! I have never kept lactulose in the fridge and hasn't done any harm :ybiggrin: -not noticeably anyway. Do you mind if I ask what this test is about? Have never heard of it

 

[DustyKat]

I’m not sure if the mannitol and lactulose they gave you is different to its other presentations but if not then normally neither is refrigerated as they are stable at room temperature.

Specimens on the other hand would need to be refrigerated.

I hope all is well cic and the test is unaffected. :ghug:

Dusty. xxx

 

[crohnsinct]

Good to hear that Dusty. I mean it is just basically sugar right? I did refrigerate the specimen but since it was first urine of the day and we went right away up to hospital I am sure it didn't get very cold. In hindsight, maybe I should have transported it in a cooler. I am just a royal screw up. :ybatty:

Anyway, she was fine.

Sascot: I understood perfectly yesterday but it is before coffee this a.m. so here is something from one of the labs who developed the test. Our doc is researching genetic vs. environmental link to Crohns and thinks taking the before dx test 3 years ago and comparing it to the one after dx may help. Also, he is thinking it might be another useful tool to monitor disease activity and response to treatment with small bowel disease. Either way is fie with me as he is picking up the tab for the test.

Intestinal Permeability Assessment

Intestinal Permeability Assessment is a powerful noninvasive gastrointestinal test assessment of small intestinal absorption and barrier function in the bowel. The small intestine uniquely functions as a digestive/absorptive organ for nutrients as well as a powerful immune and mechanical barrier against excessive absorption of bacteria, food antigens, and other macromolecules. Both malabsorption and increased intestinal permeability (â¿¿leaky gutâ¿) are associated with chronic gastrointestinal imbalances as well as many systemic disorders.

Increased intestinal permeability (leaky gut) of the small intestine can:
•Increase the number of foreign compounds entering the bloodstream
•Allow bacterial antigens capable of cross-reacting with host tissue to enter the bloodstream, leading to auto-immune processes
•Enhance the uptake of toxic compounds that can overwhelm the hepatic detoxification system and lead to an overly sensitized immune system

Leaky gut has been observed in a range of disorders such as:
•Inflammatory Bowel Disease (IBD)
•Food allergy
•Inflammatory joint disease
•Chronic dermatologic conditions

Studies have demonstrated that the increased intestinal permeability observed in patients with ankylosing spondylitis, rheumatoid arthritis, and vasculitis may be an important factor in the pathogenesis of these disorders.

Decreased permeability, on the other hand, appears as a fundamental cause of malabsorption, subsequent malnutrition, and failure to thrive. In certain disease states of the small intestine, such as gluten-sensitive enteropathy, permeability to large molecules may increase while permeability to small molecules decreases - a result of damage to the microvilli. As a result, nutrients become even less available to assist in the detoxification of antigens flooding the system.

Possible causes of increased intestinal permeability (leaky gut) include:
•Intestinal infection
•Ingestion of allergenic foods or toxic chemicals
•Deficient secretory IgA
•Trauma and endotoxemia
•NSAIDs

The Intestinal Permeability Assessment gastrointestinal test directly measures the ability of two non-metabolized sugar molecules to permeate the intestinal mucosa. The patient drinks a premeasured amount of lactulose and mannitol. The degree of intestinal permeability or malabsorption is reflected in the levels of the two sugars recovered in a urine sample collected over the next 6 hours.

 

[DustyKat]

I wouldn’t worry about the refrigeration time with a first of the morning specimen and quick transportation.

Dusty.

 

[DustyKat]

Oh and put that bat down, you aren’t THAT bad! :lol:

 

[crohnsinct]

Oh man! I just dissed you on another thread and now you go and be all nice. Now I look like the bully city girl:stinks:

 

[DustyKat]

Look like?! You are! :ylol:

 

[Tesscorm]

The bat is small potatoes for her... Don't forget she's experienced with the 'pole'.

 

[DustyKat]

Ooooooo, I hope hubby doesn’t have an inferiority complex with competition like that!. :eek2: