Hi there babycakes, and welcome to Humira ! I did the loading phase of Remicade, but had a bit of a reaction to it (seizures and vomitas maximus) So about 18 months ago I was switched to Humira. Love it, been in remission now for about 4 months, with no side effects . Also on max dose of azathioprine, the combo seems to work for me. As for the "hokey pokey" side of things ,it really is not a big deal. The pre-filled syringe is what i prefer ,as i can determine how fast to administer the drug. The needle is small, and a bit of ice to numb the area is nice too. Wipe with alcohol swab after ice,before needle. Ice can be unsterile! Then pen can also be used ,but some dont hold it close enough to the skin and it squirts all over the place (expensive!!) anymore questions, just ask. cheers