This might also apply to crohn's, don't know.
When the doc's say AIEC they really mean biofilm.
Since this is a crohn's centric forum, will add this.
http://www.ncbi.nlm.nih.gov/pubmed/23104802
http://www.biomedcentral.com/1471-2180/9/202
For me this has all come together in the last few days.
What I believe is really going on with UC.
Will try to make it as simple as possible, and explain it in pictures.
Bacteria and there biofilms should not physically touch with our colon mucosa.
In this case pictures are truly worth a thousand words, but really millions.
Why no medical cure. The medical community are not targeting the cause.
What's the cause. Persistent poly-microbial biofilm on the mucosa.
Not saying this is the initial cause, but why there is no medical cure.
Biofilms on top of or in the outer mucus, is where it belongs.
Ok so what is going on.
appendix:
If you look at the first set of pictures and read their comments, the biofilm decrease from proximal to the distal part of the colon.
Descending colon no apparent biofilm.
http://sciences.surgery.duke.edu/files/BillSection1SecondInsert.pdf
Antibiotics. Even with antibiotics the biofilm is still there, and when your done the bacteria bounce back, many fold.
http://www.charite.de/arbmkl/publikationen/2008bact_bio_suppression.pdf
You can see in these pictures that when treated with 5-asa the bacteria are suppressed but the mucosal biofilm is still there, but the immune system is functional. The bacteria are suppressed,so the inflammation is lowered,perhaps also somewhat immune modulating effect where the immune system calms down.
Now look at Azathioprine, the immune system is suppressed and the bacteria in the mucosa associated biofilm
are quite active,but you have calmed down the inflammation.
Bottom line. Whether 5-asa or immune suppression the biofilm is still there.
You can obtain remission, one way or another, but the cause of chronic UC is still present.
http://onlinelibrary.wiley.com/doi/10.1002/ibd.20003/pdf
Old Mike
When the doc's say AIEC they really mean biofilm.
Since this is a crohn's centric forum, will add this.
http://www.ncbi.nlm.nih.gov/pubmed/23104802
http://www.biomedcentral.com/1471-2180/9/202
For me this has all come together in the last few days.
What I believe is really going on with UC.
Will try to make it as simple as possible, and explain it in pictures.
Bacteria and there biofilms should not physically touch with our colon mucosa.
In this case pictures are truly worth a thousand words, but really millions.
Why no medical cure. The medical community are not targeting the cause.
What's the cause. Persistent poly-microbial biofilm on the mucosa.
Not saying this is the initial cause, but why there is no medical cure.
Biofilms on top of or in the outer mucus, is where it belongs.
Ok so what is going on.
appendix:
If you look at the first set of pictures and read their comments, the biofilm decrease from proximal to the distal part of the colon.
Descending colon no apparent biofilm.
http://sciences.surgery.duke.edu/files/BillSection1SecondInsert.pdf
Antibiotics. Even with antibiotics the biofilm is still there, and when your done the bacteria bounce back, many fold.
http://www.charite.de/arbmkl/publikationen/2008bact_bio_suppression.pdf
You can see in these pictures that when treated with 5-asa the bacteria are suppressed but the mucosal biofilm is still there, but the immune system is functional. The bacteria are suppressed,so the inflammation is lowered,perhaps also somewhat immune modulating effect where the immune system calms down.
Now look at Azathioprine, the immune system is suppressed and the bacteria in the mucosa associated biofilm
are quite active,but you have calmed down the inflammation.
Bottom line. Whether 5-asa or immune suppression the biofilm is still there.
You can obtain remission, one way or another, but the cause of chronic UC is still present.
http://onlinelibrary.wiley.com/doi/10.1002/ibd.20003/pdf
Old Mike
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