"Worms Flop in Crohn's Disease"

[kh216]

http://www.medpagetoday.com/Gastroenterology/InflammatoryBowelDisease/42805

 

[kiny]

Epidemiologic studies have found that the prevalence of inflammatory bowel disease is highest in locales where helminthic infections no longer exist

those studies ignored that people who come out of countries with low crohn's disease rates, are some of the people with the highest and most extreme forms of crohn's disease when they come to the West (canadian immigrants, indians in the UK, moroccans and middle easterners in France / Belgium)

the hygiene theory doesn't make much sense

if coming into contact with bacteria was somehow protective against crohn's disease those people should have been protected against crohn's disease, but within months of immigration, the rates of crohn's disease in those people equals and then surpasses that of the local population

a study also pointed out that the idea that an urban setting means you come less into contact with bacteria isn't always true, many new bacteria can be traced back to city dwelling animals
.

The environment somehow protects those people from getting crohn's disease, whatever is causing crohn's disease isn't present in those countries. But the people themselves are not protected, because once they immigrate they are just as vulnerable, if not more vulnerable than the natives.

 

[wild_one353]

240 patients in that study, wow!!!!!

even the earliest fecal transplant studies are like 10-20 people.

so they want worms and not bacteria hey.

 

[kh216]

I agree with Sid. Studies indicate that there is a much higher prevalence of Crohn's Disease in the northern latitudes than in the southern latitudes. We tend to get more people who post here from the northern U.S, Canada and U.K. The connection seems to be that people in the southern latitudes are getting more sunshine and are thus exposed to more natural Vitamin D. I am now taking a 1000 mg Vitamin D pill along with my multivitamin.This also helps my bones.

 

[Xiaofa Qin]

240 patients in that study, wow!!!!!

even the earliest fecal transplant studies are like 10-20 people.

so they want worms and not bacteria hey.

In fact, the early study on Trichuris suis eggs for IBD also had only several patients-four patients with Crohn's disease (CD) and three with ulcerative colitis (UC) (Summers RW, et al. Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease. Am J Gastroenterol. 2003 Sep;98(9):2034-41) with remission rate of 100% for UC and 86% in total.

 

[Poppysocks]

I agree with Sid. Studies indicate that there is a much higher prevalence of Crohn's Disease in the northern latitudes than in the southern latitudes. We tend to get more people who post here from the northern U.S, Canada and U.K. The connection seems to be that people in the southern latitudes are getting more sunshine and are thus exposed to more natural Vitamin D. I am now taking a 1000 mg Vitamin D pill along with my multivitamin.This also helps my bones.

Well,

I've lived in Florida my entire life, the sunshine state. And my Crohns is about as severe as they come.

I really doubt sunshine has anything to do with it. I think a more plausible explanation is underdeveloped countries don't have a manipulated food supply.

 

[Passing Through]

I really doubt sunshine has anything to do with it.

Evidence clearly suggests it has a role, but of course it's not the only factor. I agree that what we eat has a tremendous impact. Allot of store bought food is no longer natural, we are depriving ourselves of things we need and over each generation weakening ourselves more and more. Our epigenome and the state of our mitochondria are passed down to the next generation- we inherit it. It's why each year, people who are younger and younger are getting these issues now.

Fascinating discussion.

 

[kiny]

NOD2 interacts with the VDR gene, Vitamin D receptor, NOD2 itself interacts with ATG16L1 which is related to autophagy and the control of intracellular pathogens.

Both NOD2 and ATG16L1 are very important if not the most important genes related to crohn's disease.

Vitamin D definitly relates to crohn's disease in some way, when you hear that vitamin D is an antimicrobial vitamin, they're not lying. It's very important in control of infections.
.

What's more Vitamin D Receptor polymorphism in people actually predisposes you to having crohn's disease.

And again, it is specific for the disease with autophagy deficiencies, Crohn's disease, not UC which is a completely different disease.

It is a real shame that the term "IBD" is still being used for two completely different diseases.

 

[Passing Through]

Vitamin D Receptor polymorphism in people actually predisposes you to having crohn's disease.

And again, it is specific for the disease with autophagy deficiencies, Crohn's disease, not UC which is a completely different disease.

No kidding? That doesn't surprise me, since I have UC and for me it's less about the Vitamin D specifically and more about the other effects sunlight have- but I don't want to hijack this discussion any more then I have, since it's primarily about something else.