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I got an ostomy reversal on December 2023 after having my second bowel ressection. I only had the ostomy for 3 months before it got reversed. Since the reversal, I pretty much only have loose stools. There is no sense of urgency. I only go 2 times per day. My most recent colonoscopy, CRP, and...

Hey James! What sort of Crohn's symptoms are you experiencing? Bloody stools, diarrhea, abdominal pain, weightloss, etc. I think it is worth discussing with your GI and if you're diagnosed with Crohn's, a good GI will continue you monitor you with colonoscopies and fecal calprotectin. In...

Biologics (e.g. TNF-alpha inhibitors like Humira, IL-23 inhibitors like Skyrizi, etc.) all fall under the category of monoclonal antibodies. The immune system is able to recognize these antibodies and may "destroy" them resulting in medication failure. Upadacitinib (Rinvoq) is NOT a biologic...

Take a closer look at the second study posted by Kiny (Panes et al.) You can see that the placebo group was on corticosteroids during both the induction and maintenance study at which they were receiving a very slow 5 mg taper. Steroids work like a charm and pushing people into...

Tofacitinib and Filgotinib is literally not approved and most likely will not be approved for Crohn's disease so what is the point of discussing the efficacy of these two drugs when there is Upadacitinib, a JAK-1 selective inhibitor, that has been approved for Crohn's. Upadacitinib Induction...

Simply saying "X inhibitors have very serious side effects" is really a null point. All biologics, TNF-alpha, integrin inhibitors, Jak inhibitors all have potentially serious side effects. For the most part, all the serious side effects associated with biologics are extraordinarily small. The...

Hey James I know you were looking for an update so I made a new response above. Could I ask you what type of exercise you are doing and if you are in remission? What are you fecal calprotectin levels looking like?

Hi everyone! Just wanted to provide a small update. I've been resistance training and running for the past 12-weeks and things are going great! I've gained around 25 lbs. (120 lbs. --> 145 lbs.) and my lifts and mileage has been improving each week. I train hard. I lift 4x a week...

If you happen to eat something with seeds, do you suffer for a day and then go back to normal or is it something that messes you up for a couple days?

Are you able to provide a study that makes you so confidently say they lack effectiveness in Crohn's disease? Also, Rinvoq is a second-generation JAK inhibitor that targets specifically JAK1 versus first-generation JAKi that tend to inhibit JAKs rather unspecifically.

Hello, Currently around 7-weeks post-op and prior to the ostomy reversal I was told my bloodwork, stool work, and colonoscopy came out entirely clean. So, they reversed me and things have been well. I am pretty much eating like normal. Fruits, vegetables, etc. but I noticed that certain foods...

Hey James. O' man. So many updates. I ended up getting a serious GI bleed and ended up in the hospital last year. Skyrizi definitely helped to some degree, but my inflammation was too bad to be honest and it would have never been enough to completely settle things entirely. Anyways, I had an...

Looking to get a discussion started on powerlifting with Crohn's. Especially considering how taxing heavy lifting is on the body and the large involvement of the core musculature. So, if you are a powerlifter and have Crohn's disease, please share your story and what you learned along the way!

Thanks for letting me know! Were they still the same color (orange-ish?) or did it change color to something else? Anyways, I'll let you know how it goes for me. Maybe other Crohnies experiencing the same thing will get benefit from our experience.

Glad that worked out for you! I plan on switching my Rinvoq over to nights starting tomorrow...(I started up Rinvoq today, so I don't think it'll be too much of an issue). I'm glad that worked out for you because even before you posted, that was my plan. The reason being that I take...

I am currently on Rinvoq as well. What do you mean by "residues in his poops". Would you be able to elaborate on its appearance? I have pills coming out of my ileostomy/stool (prior to getting my ileostomy) and would like to see what your "residues" look like because I have not been able to find...

Any Crohn's patients currently taking Rinvoq that has experience with finding pills in their stool?

Hello, Recently got an ileostomy done and I've noticed that I am seeing medication pills in my ileostomy. First, it started with pantoprazole, and now I think I'm noticing my Rinvoq in my ileostomy bag as well. Has anyone had experiences like this and what are they doing to help prevent this...

I'm so sorry to hear that. As a patient with IBD, you really have to advocate for yourself. In your circumstance, you really have to learn to be the advocate for your child. Call your insurance and ask to get an expedited review. If they are unable to do that, call your doctors office and ask...

Trying to exercise is a challenge that I have been experiencing myself with my disease. I'm not interested in exercises like tai chi or yoga. My passion is and will always be powerlifting and bodybuilding, yet, my body gives out on me each time I try to engage in it. I believe it is possibly...