Antibiotics
Antibiotics are important for treating Crohn's disease that is accompanied by fistulas, bacterial overgrowth, abdominal abscesses, and any infections around the anus and genital areas.
Typical antibiotics are ciprofloxacin (Cipro) and metronidazole (Flagyl), which are used for infections caused by anaerobic bacteria (organisms that can exist without oxygen and often cause abscesses and abdominal and gynecologic infections). Either antibiotic, used alone or in combination with other agents, is effective and has produced disease remission rates of about 70% that last a year. Ciprofloxacin is the antibiotic of choice, however. In one study it was as effective as mesalazine for patients with mild to moderate Crohn's disease. And a 2000 study reported that an antibiotic regimen achieved quick remission in children with Crohn's without the need for steroids.
Other antibiotics used for Crohn's disease include trimethoprim/sulfamethoxazole (Bactrim, Cotrim, Septra) and tetracycline.
Stopping antibiotics brings on relapse, so long-term therapy is required, carrying a risk for side effects, including numbness and tingling in the hands and feet.
