butyrate

[cheka]

this family of diseases has issues with butyrate. where does butyrate come from? it comes from the beneficial bacteria in our guts. how do we get these bacteria in our guts to make the butyrate? probiotics and prebiotics (bugs and bug food). low butyrate also causes colon cancer. heads up on that

these guys muse about doing just that -- manipulation of microbial synthesis

https://pubmed.ncbi.nlm.nih.gov/29373727/
Determinants of Reduced Genetic Capacity for Butyrate Synthesis by the Gut Microbiome in Crohn's Disease and Ulcerative Colitis

Conclusions: Reduced butyrate-synthetic capacity of the microbiota is more evident in CD than UC and may relate to reduced fibre intake. The results suggest that simple replacement of butyrate per se may be therapeutically inadequate, whereas manipulation of microbial synthesis, perhaps by dietary means, may be more appropriate.

 

[cheka]

butyrate shortage sets off cascade of events. anaerobic environment looses it's integrity....then off to the races. my bold

https://pubmed.ncbi.nlm.nih.gov/35901721/

 

[cheka]

it's best to grow your population of gut butyrate producers, esp the bifid family of bugs, to rectify butyrate shortages. another thing would be to ramp up ingestion of butter, real butter. real butter is packed with butyrate. i would not use this as the primary treatment for low butyrate, but add it to an ongoing program to increase the all-important bifid bugs. me and mine take 2-4 tablespoons per day

 

[cheka]

inulin fiber increases butyrate producers, helps with leaky gut

massive paper, just grabbed a few clips to paste. my bold

https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.01832/full

 

[cheka]

this guy does a nice writeup on inulin. bonus points for him covering the all important bifid family of bugs, prolific butyrate producers. my bold

https://www.ericfavre.com/lifestyle...organs-of-detox/liver-detox/inulin-and-detox/

 

[cheka]

new paper published. whole thing is a good read. pasting the excellent explanation of the chain reaction initiated from a low number of butyrate/scfa producing bacteria.

we can work on that. the bifid bacteria family are prolific butyrate producers and feeding them inulin really gets them going.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10975629/

 

[cheka]

this 2024 paper names some specific bugs. all of them are readily available. i take almost all of them daily.

https://www.uspharmacist.com/article/emerging-therapies-for-ulcerative-colitis-induced-pain

 

[cheka]

more on butyrate --- a KEY product of the bacteria and critical to our immune systems

https://www.cell.com/cell-metabolism/pdfExtended/S1550-4131(20)30118-2
Microbiota-Derived Metabolites Suppress Arthritis
by Amplifying Aryl-Hydrocarbon Receptor Activation
in Regulatory B Cells

https://pubmed.ncbi.nlm.nih.gov/32711255/
Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells

 

[cheka]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002420/
Butyrate and the Fine-Tuning of Colonic Homeostasis: Implication for Inflammatory Bowel Diseases

 

[cheka]

pasted summary. link to full paper at link (top right corner of page)

https://pubmed.ncbi.nlm.nih.gov/16225487/

 

[cheka]

https://pubmed.ncbi.nlm.nih.gov/37242159/
Gut Microbial Metabolite Butyrate and Its Therapeutic Role in Inflammatory Bowel Disease: A Literature Review

Results: Research in the last two decades has shown the beneficial effects of butyrate on gut immune function and epithelial barrier function. Most of the preclinical and clinical studies have shown the positive effect of butyrate oral supplements in reducing inflammation and maintaining remission in colitis animal models and IBD patients. However, butyrate enema showed mixed effects. Butyrogenic diets, including germinated barley foodstuff and oat bran, are found to increase fecal butyrate concentrations and reduce the disease activity index in both animal models and IBD patients.

 

[cheka]

https://pubmed.ncbi.nlm.nih.gov/34494943/

 

[cheka]

here they find that inflammation can reduce butyrate uptake

https://pubmed.ncbi.nlm.nih.gov/31211831/
Intestinal Inflammation Modulates the Epithelial Response to Butyrate in Patients With Inflammatory Bowel Disease

Butyrate-producing gut bacteria are reduced in patients with active inflammatory bowel disease (IBD), supporting the hypothesis that butyrate supplementation may be beneficial in this setting. Nonetheless, earlier studies suggest that the oxidation of butyrate in IBD patients is altered. We propose that inflammation may decrease epithelial butyrate consumption.

 

[nofun]

A study using primary intestinal epithelial monolayers from UC patients found that butyrate did not protect against inflammation-induced barrier dysfunction, and even worsened the effects of inflammatory cytokines

https://academic.oup.com/ecco-jcc/article/13/10/1351/5421326

We found that butyrate does not protect against inflammation-induced barrier dysfunction and even worsens its effects in primary epithelial monolayers of UC patients and controls. The basic mechanisms of butyrate should therefore be reconsidered in future studies, in particular in patients with active inflammation and pre-existing barrier defects as is known for UC.

 

[cheka]

A study using primary intestinal epithelial monolayers from UC patients found that butyrate did not protect against inflammation-induced barrier dysfunction, and even worsened the effects of inflammatory cytokines

https://academic.oup.com/ecco-jcc/article/13/10/1351/5421326

We found that butyrate does not protect against inflammation-induced barrier dysfunction and even worsens its effects in primary epithelial monolayers of UC patients and controls. The basic mechanisms of butyrate should therefore be reconsidered in future studies, in particular in patients with active inflammation and pre-existing barrier defects as is known for UC.

this seems to rhyme with the paper just above it. inflammation hinders uptake.

 

[cheka]

deep dive paper

https://www.mdpi.com/2673-5601/2/4/42

 

[cheka]

https://www.nature.com/articles/s41598-017-11734-8

 

[cheka]

https://www.nmi.health/butyrate-therapy-for-treatment-resistant-ulcerative-colitis-a-case-study/
Butyrate Therapy for Treatment-Resistant Ulcerative Colitis: A Case Study

Conclusion

This case report suggests a novel role for oral butyrate therapy. In a case of UC that was resistant to conventional therapy and nutritional interventions, butyrate administration appeared to result in significant control of symptoms and maintenance of remission. It is hypothesised that this may be due to exogenous butyrate supporting an individual’s higher metabolic demand for endogenous butyrate that could not be met due to impaired butyrate synthesis and/or increased metabolic requirement, although this theory requires validation with more research. Evidence to date suggests that butyrate may be a useful, safe therapy that could complement the usual care of IBD.

 

[cheka]

tables and graphics at link

https://academic.oup.com/ecco-jcc/article/18/Supplement_1/i1590/7586908

 

[cheka]

https://www.mdpi.com/2673-5601/2/4/42
25 November 2022

Regardless of genetic background, the number of patients with IBD has increased. This phenomenon suggests that the rapid increase in the incidence of IBD is parallel to changes in lifestyle, such as diet, breastfeeding, and antibiotic use [3]. Additionally, these parameters are closely related to the gut microbiota.

Patients with IBD demonstrate significantly decreased microbial diversity and short-chain fatty acids (SCFAs) compared with healthy controls [4,5,6]. This suggests that environmental factors, such as microbiota and diet, contribute to abnormal immune responses during the onset of IBD.

Recent studies have shown that microbial diversity and fecal abundance of butyrate influence the success of biological therapies and thiopurine treatment [7,8,9,10]. These results suggest that interactions between intestinal dysbiosis and the host response are involved in both the onset of IBD and treatment outcomes. In this review, we describe the multiple effects and advanced therapies of butyrate, as well as the regulation of butyrate uptake into intestinal epithelial cells (IECs).