The first time I was on Entocort, I recall having about 1-2 bad days per week (nausea, diarrhea, etc). When I finally came off of it, then I felt much better and was in remission. The path to remission is not always easy, it seems. I presume it was the Entocort causing those bad days at the same time it was healing my insides, but I don't know for sure or what the process was that was happening. Entocort also gave me cluster headaches which was not a fun time, but I was in remission for 2 years after coming off of Entocort so I feel like it was worth it.