Crohns,does it lower your immune system?

[beefcake]

Four years ago,(3 months after a resection) I had a tooth implant,I've had three infections in it,and now may have to have it out !
Am I just unlucky,or does having Crohns make me be in a higher risk for infection ?
Thanks in advance

 

[Lowbudge]

I know when I have dental work done I recover slow. I was told the anesthesia reacts weird with people and Crohns. The 2 things ( Wisdom ) I had done really left me flaring up something bad and it took me a week to recover.

It could be our system that reacts funny.:frown:

 

[kiny]

Crohn's (active disease) doesn't lower your immune system.

But most (all? open question) people with crohn have a weakened immune response.

Reason for this is genetics, NOD2 and ATG16L1 are often mutated (slightly defective if you will) in people with crohn.

NOD2 and ATG16L1 are both directly involved in autophagy, autophagy is crucial to stop infections. NOD2 is able to recognise bacteria, and it recruits ATG16L1 protein to the site of infection, NOD2 can down or upregulate the defense mechanism of autophagy.

The test to show this is what happens in people with CD have been many, because it's an easy test. You take a harmless pathogen, you inject it in a person with crohn and you do the same thing in a healthy person, you check the blood and see who clears the bacteria fastest, the person with crohn will be slower.

 

[jmariel]

Personally with me, yes absolutely. Each year I have head colds that don't pass on their own, and usually spread to my ears. The last one was so bad it ruptured my ear drum and took 3 courses of antibiotics to clear up. I'm guessing next year I will go deaf.

 

[chunky]

i seem to be ok when it comes to colds and flus but i did have shingles 7 times in 6 years so i must have some kind of immune issue going on the shingles were awful but the drugs were great lol

 

[Jennifer]

Every GI doctor I've seen has said that it does and I got sick fairly often even before I started 6MP.