Higher Vitamin D Levels are Associated with Improved Outcomes in IBD Patients Treated with Entyvio

[Scipio]

https://www.mdpi.com/2072-6643/15/22/4847
From the paper:

Conclusions
Our retrospective study of patients on vedolizumab therapy for both UC and CD found that higher pre-treatment vitamin D levels were associated with higher endoscopic improvement in UC and greater nutritional and supplementation improvements in iron saturation and B12 levels in CD. Those with higher vitamin D levels had higher vedolizumab drug levels in the CD population. In our CD patients, greater improvement in vitamin D levels correlated with lower CRP levels. This study suggests that vitamin D can play a role in clinical and endoscopic outcomes and should be assessed routinely and optimized in patients with IBD in a prospective study.

 

[wild_one353]

I take 2000iu per day, all year long. The upper level limit is about 4000iu per day depending on individual factors like age body weight etc. There are quite a few studies that show benefits for vitamin d supplement on IBD.

Here is a study from 2013 that gave 18 crohn's patients 5000iu vitamin d for 6 months, and most patients CDAI were reduced and most were considered to be in clinical remission.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636524/

 

[lukesjr]

There is a book on amazon called The Miraculous Results Of Extremely High Doses. Its a good book, obviously don't take it as medical advice. But there is a case in there of a person with crohns whose doctor prescribed 50000 iu of vitamin D once per week for a month and it put the person in remission. Who knows if its true. But I have been taking vitamin D since my first diagnosis, along with a bunch of other natural stuff and have been pretty consistent, all diagnostics show no crohns.

I suspect all the other stuff has done nothing (fiber, tumeric, and the list goes on) but it was the vitamin D.

What I did do, for those that want to try, is have my doctor measure my vitamin D with my blook work every time. I took 5000 iu per day (I am 190 lb man) and that put me from around 25 nmol/L to around 85 nmol/L. If you read the literature, less than 30 is deficient greater than 75 is considered therapeutic. >150 is considered to have adverse effects.

I think a lot of this makes sense when you think of human history. Up until a very recent times humans spent most of their time outdoors. Not until the industrial age did people move indoors for work. So vitamin D deficiency is a relatively new thing when thinking of all of human history.

 

[wild_one353]

There is a book on amazon called The Miraculous Results Of Extremely High Doses. Its a good book, obviously don't take it as medical advice. But there is a case in there of a person with crohns whose doctor prescribed 50000 iu of vitamin D once per week for a month and it put the person in remission. Who knows if its true. But I have been taking vitamin D since my first diagnosis, along with a bunch of other natural stuff and have been pretty consistent, all diagnostics show no crohns.

I suspect all the other stuff has done nothing (fiber, tumeric, and the list goes on) but it was the vitamin D.

What I did do, for those that want to try, is have my doctor measure my vitamin D with my blook work every time. I took 5000 iu per day (I am 190 lb man) and that put me from around 25 nmol/L to around 85 nmol/L. If you read the literature, less than 30 is deficient greater than 75 is considered therapeutic. >150 is considered to have adverse effects.

I think a lot of this makes sense when you think of human history. Up until a very recent times humans spent most of their time outdoors. Not until the industrial age did people move indoors for work. So vitamin D deficiency is a relatively new thing when thinking of all of human history.

typically, in studies, daily doses are healthier and have less side effects then larger weekly doses. 50,000iu a week is 7142iu per day, so that is a similar dosage in the study I posted. Its probably only usefull to take higher doseage the the RDI if your symptoms are really active and you might have absorption issues. If someone isnt checking their blood levels, id say stick to a safe dose within the RDI.