I just spoke to someone at the pharmacy that will be sending me the Humira. She said you can expect to see some slight reddening of the skin and possibly some bruising at the injection site, but if it's more than a little bit, then you need to call the doctor. Also, she said because Humira suppresses the immune system, to be diligent about washing your hands and using hand sanitizer. Too, if you feel like you're coming down with an upper respiratory infection or a bladder infection, to call the doctor. Dontcha just love having IBD? Not! Good luck to you. Let us know how it goes!