Sharing this https://www.medpagetoday.com/infectiousdisease/covid19/91775
About this study https://jamanetwork.com/journals/jama/fullarticle/2777685 and an ongoing study vaccineresponse.org
You need to register (free) to see the video or read the interview transcript with researcher Dorry Segev, MD, PhD, associate vice chair of surgery at Johns Hopkins University School of Medicine and professor of epidemiology at Bloomberg School of Public Health. The interview is about a recent study which measured antibodies in transplant patients who received a Covid-19 vaccine. The study found that only 17% had measurable antibodies after dose 1 as opposed to "basically" 100% in people with normal immunocompetent people according to big randomized patients. Only 8% of transplant patients on azathioprine had antibodies after dose 1.
Yes this study was on transplant patients but there is also another study that deals with chronic conditions including Crohn's.
From the interview:
"Makary: What does this mean? You studied organ transplant recipients. What does this mean for say non-organ transplant recipients who are on immunosuppressive medications for other reasons?
Segev: So we are studying that. So we have a parallel study, vaccineresponse.org, which covers people with chronic conditions. A lot of which either the condition itself or the medications they take are immunosuppressing. And so we're studying people with autoimmune disease, IBD, cirrhosis, ESRD, HIV, et cetera. We're just starting to get data from that. I'll give you kind of the, the gestalt is that if you are on immunosuppression agents, such as mycophenolate, azathioprine, you will probably have a blunted immune response, no matter what reason [there] is for taking those immunosuppression agents."
Dorry Segev, MD, PhD, says "I would love for the CDC to say much more firmly, if you are taking immunosuppression do not assume you have immunity because you have been vaccinated."
My take:I think this is important since the current CDC guidelines seem to assume immunity if you are 2 weeks post second COVID-19 vaccine but if you are on azathioprine, and possibly other immunosuppressants, that may not be true.
If you haven't had your COVID vaccine, vaccineresponse.org is currently enrolling people with chronic conditions like Crohn's. "The purpose of this research study is to determine COVID-19 antibody levels in patients with chronic conditions who receive the COVID-19 vaccine. The study does not provide the vaccine, and study team members will not be offering guidance as to whether one should or should not receive the SARS-CoV-2 vaccine. If participants will be receiving a vaccine and are interested in the study, we will collect a sample before vaccination, and collect samples at sequential time points post-vaccination to determine antibody levels." People enrolled in the study are told if they have detectable antibodies to Covid-19.
About this study https://jamanetwork.com/journals/jama/fullarticle/2777685 and an ongoing study vaccineresponse.org
You need to register (free) to see the video or read the interview transcript with researcher Dorry Segev, MD, PhD, associate vice chair of surgery at Johns Hopkins University School of Medicine and professor of epidemiology at Bloomberg School of Public Health. The interview is about a recent study which measured antibodies in transplant patients who received a Covid-19 vaccine. The study found that only 17% had measurable antibodies after dose 1 as opposed to "basically" 100% in people with normal immunocompetent people according to big randomized patients. Only 8% of transplant patients on azathioprine had antibodies after dose 1.
Yes this study was on transplant patients but there is also another study that deals with chronic conditions including Crohn's.
From the interview:
"Makary: What does this mean? You studied organ transplant recipients. What does this mean for say non-organ transplant recipients who are on immunosuppressive medications for other reasons?
Segev: So we are studying that. So we have a parallel study, vaccineresponse.org, which covers people with chronic conditions. A lot of which either the condition itself or the medications they take are immunosuppressing. And so we're studying people with autoimmune disease, IBD, cirrhosis, ESRD, HIV, et cetera. We're just starting to get data from that. I'll give you kind of the, the gestalt is that if you are on immunosuppression agents, such as mycophenolate, azathioprine, you will probably have a blunted immune response, no matter what reason [there] is for taking those immunosuppression agents."
Dorry Segev, MD, PhD, says "I would love for the CDC to say much more firmly, if you are taking immunosuppression do not assume you have immunity because you have been vaccinated."
My take:I think this is important since the current CDC guidelines seem to assume immunity if you are 2 weeks post second COVID-19 vaccine but if you are on azathioprine, and possibly other immunosuppressants, that may not be true.
If you haven't had your COVID vaccine, vaccineresponse.org is currently enrolling people with chronic conditions like Crohn's. "The purpose of this research study is to determine COVID-19 antibody levels in patients with chronic conditions who receive the COVID-19 vaccine. The study does not provide the vaccine, and study team members will not be offering guidance as to whether one should or should not receive the SARS-CoV-2 vaccine. If participants will be receiving a vaccine and are interested in the study, we will collect a sample before vaccination, and collect samples at sequential time points post-vaccination to determine antibody levels." People enrolled in the study are told if they have detectable antibodies to Covid-19.
