I've been on Imuran and Humira for about 6 weeks now. So far so good. White cells are holding up but I'm still anemic, apparently bleeding for 2 years will do that. I did get the blood test to make sure that I could metabolize the Imuran. I refused to take it other wise, my doc was very annoyed but it's my health not his! I strongly suggest getting the blood test but it is spendy. The humira shots don't hurt if I do them in my stomach, on my thigh they burned bad. Turns out the metformin for my type 2 diabetes IS part of the problem. Why he would give me something that causes diarrhia when I already HAVE diarrhea ? Doctors are stupid sometimes. You never should just take their word for it!