New treatment options showing higher response rates than anti-TNF drugs

[Keepingfaith]

I don't know if someone has posted this already(sorry if they have!)but I came across this & it made me happy :dance:

http://egmnblog.wordpress.com/2012/06/21/new-anti-inflammatory-drugs-will-end-anti-tnf-dominance/

 

[Amy (worrywart)]

Wow that's great news ",) nice to hear something positive x
Thanks so much for sharing the link x

 

[ndw0317]

Very nice to hear something positive!!!!

 

[Mountaingem]

:dance:Yay! Thank you so much for posting this! I've had Crohn's for 25 years (I'm 39) so it's always been a little scary to me that I'm running out of medication options.

 

[Ian]

I've been hoping for Vedolizumab to become available for a while now. I once heard 2012. Then I heard 2013. I don't think this article states an ETA (read it last week) but I heard someone say 2016 somewhere the other day... hurry up already! It sounds like it could turn things around for a lot of people.

 

[Keepingfaith]

Hahaha I know! I try not to get my hopes up too high when it comes to drug release dates. So many things can go wrong and set the release dates back further & further. I'm just glad they are atleast trying to find more beneficial treatments!

Someone told me recently that their GI told them a cure for Crohn's should be available in the next five years. It took all the self control I had to bite my tongue

 

[kiny]

Don't know why people get so excited about medication like this. This is a modified version of a medication that was straight up killing people and was taken off the market, they have now modified that medication and "claim" that the majority of the drug doesn't affect the brain.

The reason this medication is even coming out and is set to replace TNF-alpha blockers is because the rights on TNF-alpha blockers are expiring and they want to keep making money.

 

[Keepingfaith]

The way I look at it is: Would I rather have this disease 40 years ago, when the main treatment option was long term steroid use or would I rather have this disease in this day and age, when their is at least more treatment options for those who can not tolerate antibiotics, SCD, Paleo, Immunosuppressants, EN, 5ASA's etc. for one reason or another.

Everyone has different life styles, cultures, religions etc. I know a lot of people like to push certain diets/medications but that isn't the cure all for everyone and it isn't suitable for people with other medical illnesses/religions. This forum is a place for support. I don't agree with how some people treat their disease but I am not them nor do I know their lifestyle/other medical conditions. We're all in this together and we all want the same thing: To feel better. If you feel better by following a certain diet/treatment than that is fantastic. If someone else feels better doing something completely different then that's fantastic also.

 

[kiny]

Not sure what that has to do with anything. That medication you posted is a derivative of a medication that was taken off the market because it was killing people, that article completely ignores that. People should know what they're getting, that trial killed people, it's one step away from poison.

 

[Keepingfaith]

Chemo & radiation kills people also but should that be taken off the market?

Part of your above mentioned statement had nothing to do with what I posted. I didn't tell people to hop on the trial & I most certainly didn't say these drugs didn't have risks. Please point out where I was advocating this drug & telling people to get into trial and witholding information about the trials. I did neither.

 

[kiny]

People who go onto chemo are suffering from a life-threatening disease. Crohn is not a life threatening disease.

I understand that you weren't advocating it, but that blog post should mention what happened with their first trials. A lot of companies are in it for the money, that trial was a disaster and a disgrace to all the families that lost people. I'm amazed they are even allowed to reintroduce that medication under another name just because the modified version doesn't affect the brain they claim, even though reports of people getting side effects like nightmares and dizziness are already surfacing.

I really hope that people who participate in trials think twice.

 

[Igor_Passau]

I found one person with UC! He is on Wedolisumab! He is participating in clinical tries ! He is on this more then 1 year! It was only one relaps and he was again in hospital on the high dose of prednisolon. About side effect - infections! but he told me this is better that operation !

 

[Mark in Seattle]

kiny, do you have any more specific info regarding the derivative drug and/or trials which caused deaths?

I was just trying to look into this since I'm not familiar. kiny, correct me if I'm wrong, but having poked around on the internet, I'm now inferring that you're meaning to say that Vedolizumab is a second generation version of Tysabri (Natalizumab) - is that your point? But when I try to research Tysabri, I don't see any mention of deaths from trials, but I see mention of 31 deaths due to progressive multifocal leukoencephalopathy (PML) after the drug was approved for use in USA and/or Europe (the specifics are not 100% clear to me from my read of Wikipedia). So is this what you're talking about or something else?

Also, from what I'm reading, Vedolizumab only targets the gut, rather than being more systemic like Tysabri, so perhaps it has a better safety profile. Or maybe that's a myth (I note the comments on this site regarding nightmares, etc. http://www.crohnsforum.com/showthread.php?t=16116)

I also read that Vedolizumab is showing positive results for UC, but not really for CD. I have no stance toward any of these drugs, I'm just trying to better understand and get some more clarity into this thread about the pros and concerns that have been touched upon here.

I'm not sure how much to fault the blogger for failing to raise concerns, as it seems like a pretty cursory report.

But I think this is great that kiny has raised some concerns. I would definitely think twice and dig deeper before trying this med. Any med that reports to mess with a person's mental faculties is something I would tend to avoid like the plague.

 

[kiny]

but I see mention of 31 deaths due to progressive multifocal leukoencephalopathy (PML) after the drug was approved for use in USA and/or Europe (the specifics are not 100% clear to me from my read of Wikipedia). So is this what you're talking about or something else?

Right, the claim is now that the medication isn't influencing the brain anymore but is localised to the gut, but I don't believe it one bit, I looked over the side effects of people and many are focused on the head, dizziness, nightmares, sleep deprivation. I really hope people are careful, that's really all, because that trial was one of the biggest tragedies ever for crohn trials.