By picoprep, do you mean picolax, pico salax, or prepopik? (Same prep, different names depending on which country you're in.) If so, yes, I did prepopik for my last prep. It was almost too gentle on me! It was easy to drink - just 2 little cups of prep (plus a bunch of other clear liquids of your choice, to stay hydrated). The prep didn't taste bad, it was almost nice. It did make me pretty nauseous, but I had some Zofran on hand which took the edge off the nausea. It didn't make me go and go, though. I went a few times after each cup, but I wasn't fully empty yet, so I ended up taking some dulcolax as well. Things finally kicked into gear about an hour before my scope, and just as they got me hooked up to the IV and the heart rate monitor and all that stuff, that's when I had to get unhooked quickly and run for the bathroom (and I had to keep getting unhooked to run to the bathroom repeatedly while waiting to be wheeled back to the procedure room!). In the end, I was clear enough to be scoped. But if this is the same prep you're doing, I'd suggest having an anti-nausea med handy, and be prepared to take more laxatives if you don't go enough to get cleaned out. Other than those two issues, I did fine with prepopik.