My husband recently had a crohn's flare and was hospitalized. He thought he had an obstruction, but the CT scan showed no blockage and a little inflammation from the Crohns. They had him on 40 m.g. of prednisone while in the hospital for 4 days and his GI doc continued him at 40 m.g. for another 2 weeks. While in his second week of therapy, he developed this burning in his upper chest. At first it would only happen if he was active (e.g. riding a bike, mowing lawn). The burning would cease as soon as the activity stopped. Now it is happening with more frequency, even when he is sitting in a chair relaxing. He called his GI and he started to taper him down the next day to 20 m.g. for 3 days and then down from there over a period of two weeks, alternating from 20 m.g. per day to 10 m.g. per day. I guess my question is, has anyone else experienced this kind of sensation? He is not short of breath, has no cough or sore throat or anything. He is going for a chest xray today and we will go from there. I have seen people complain about heart burn, but he says its not heartburn. He was on Prednisone for 8 weeks two years ago and had no bad side effects from the drug. This is crazy!