Switching from humira to cannabis

[MLinfante]

I've been taking humira for a few years. My bowels feel blocked and I usually have only gaseous liquid stools -often with mucous and sometimes blood. I have also started cannabis and hear it provides the same positive TNF effects as humira but in a more natural format. I am ready to commit myself to a better diet and make the switch away from humira but seek advice and dialogue with others who have at least chosen to discontinue humira.

 

[rusty2112]

Hello, I was required to stop using three different biologicals including Humira. I was at the end of my rope with Crohn's after a lifetime of predisone, remicade,humira,cimzia, as well as other crohn's meds. Too much surgery has also left me with very short bowel. I had absolutely nothing to loose and tried cannabis. I wish I would have tried it long ago. It is all that I use now and would say that I have not ever done as well as I am doing now. I eat anything and lots of it.

I know that it is not for everyone. It is however right for me considering where I am currently at. There is a forum just for that on this website and it is helpful to me. Take a look if you want. I think you may get more specific information.

I hope you have as much success as I have had. It helped me get what I consider to be a reasonably normal life. Contact me if you want.

 

[nogutsnoglory]

I have not heard of medical marihuana acting as an anti-TNF. Do you have a source?

I know many find it helps with pain management, increases appetite and could potentially be anti-inflammatory. Are you saying it specifically acts on TNF?

 

[LucyCarroll]

I am with you. My experiment started when I went on SCD and marijuana about 8 weeks ago. I quit Humira at the same time. So far I am hanging in and I am feeling better.

 

[my little penguin]

Unheated Cannabis extract and THCa were able to inhibit the tumor necrosis factor alpha (TNF-alpha) levels in culture supernatants from U937 macrophages and peripheral blood macrophages after stimulation with LPS in a dose-dependent manner

This inhibition persisted over a longer period of time, whereas after prolonged exposure time THC and heated Cannabis extract tend to induce the TNF-alpha level. Furthermore we demonstrated that THCa and THC show distinct effects on phosphatidylcholine specific phospholipase C (PC-PLC) activity. Unheated Cannabis extract and THCa inhibit the PC-PLC activity in a dose-dependent manner, while THC induced PC-PLC activity at high concentrations. These results suggest that THCa and THC exert their immuno-modulating effects via different metabolic pathways

From
http://www.ncbi.nlm.nih.gov/m/pubmed/16504929/

 

[Rabbita]

Why wouldn't you commit yourself to the healthy diet, try cannibis and then once you feel better quit Humira?

 

[jjk308]

http://online.ccfa.org/site/DocServer/2014.04_Velayos_Alternative_Therapies_in_IBD.pdf?docID=25685

The above has the results of a small high THC marijuana study - There were no anti-inflammatory effects. Apparently patients felt better because of the analgesic effects of THC, but it has been reported they started to feel worse shortly after the formal study ended, during a 2 week follow up as Crohn's flares burned through the THC euphoria.

Studies on the anti-inflammatory effects of low THC cannabis products are long overdue and presumed to have failed. Apparently cannabis doesn't work outside of a test tube.