For the past year or so I have been having very bad twitching with my right hand. I mean it is like you expect to see from elderly people or someone with parkinsons. This last time that I have gone up on Prednisone it has started very bad and multiple times daily. I had thought it might be a side effect of crohns or just all the years on different medicines, but from what I have read other places and also here I can just about come to the conclusion that it is the prednisone. The only time it is aggravating is when I am writing or trying to eat. It doesn't really affect typing or driving. Hopefully when I go down then it will subside.