For me, it was Humira. I was on it for 3 glorious years; was able to work full time, no naps, just 3 years of remission and normalcy for the first time in my life. I never had any side effects. It was as close to a miracle drug as there is. As all good things must come to an end, the Humira caused Lupus for me, and I had to go off of it last year. Just started on Methotrexate this past week after trying Entocort for 1 yr. Just wasn't enough though. I am super nauseaous with Metho, and I never know when it's going to hit. Super tired too. Some days I feel great, others YUCK. Hoping side effects will taper off as I keep going. I truly miss the Humira!!!