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Omvoh, another IL-23 inhibitor, is already FDA approved for UC and is now reporting good results for Crohn's and performed better than Stelara. Quote from the link: "A greater number of patients that achieved histologic response were observed with mirikizumab at Week 52 in the overall...

In patients with Crohn's disease a multicenter prospective study found that anti-TNF therapy failed to achieve remission at 3 years in about two-thirds of cases, and that high drug concentrations early in treatment are linked to greater probability of sustained remission. This suggests that...

Recent meta-analysis of 32 published studies identified exposure to certain types of chemicals and pollutants as associated with increased risk of IBD. Plastics were not specifically called out. Interestingly, exposure to zinc was found to be associated with lowered risk of IBD. Quote: "The 32...

This analysis shows that despite close concordance to human diseases, and seemingly promising early results, therapies developed from animal studies result in an FDA-approved therapy for humans only about 5% of the time: Animal studies rarely lead to approvals, new research finds...

Huge decrease of risk of developing Primary Sclerosing Cholangitis (a serious disease of the bile ducts that can lead to liver failure) is associated with statin use in IBD patients: In IBD Patients, Statin Use Associated with Lower Risk of Developing PSC | GI and Hepatology News (mdedge.com)

If there is any comfort in having an incurable, serious disease, for the Crohn's patient it may be the knowledge that at least it is usually not fatal. The life expectancy for Crohn's patients is almost the same as that of the normal population. One tragic exception to this rule was that of...

The AGA has issued new GI practice guidelines for diet and nutritional therapies for IBD: The Guideline: https://www.gastrojournal.org/action/showPdf?pii=S0016-5085(23)05597-X Summary: A Starting Point First, the panelists advise that, unless contraindicated, all patients with IBD follow a...

Bad News: Zeposia, which is already approved by the FDA for treating multiple sclerosis and ulcerative colitis, failed to hit its target endpoint in its Phase III clinical trial of Crohn's disease...

Keep those masks handy and vaccines up to date: https://www.medpagetoday.com/meetingcoverage/ccc/108524

https://www.mdpi.com/2072-6643/15/22/4847 From the paper: Conclusions Our retrospective study of patients on vedolizumab therapy for both UC and CD found that higher pre-treatment vitamin D levels were associated with higher endoscopic improvement in UC and greater nutritional and...

https://www.fiercebiotech.com/medtech/fda-greenlights-5-minute-tests-track-humira-remicade-doses-patients-inflammatory-bowel

Until now Entyvio has been by infusion only in the US: https://www.fiercepharma.com/pharma/takedas-scores-second-chance-subcutaneous-version-entyvio

https://www.prnewswire.com/news-releases/abbvies-skyrizi-risankizumab-met-all-primary-and-secondary-endpoints-versus-stelara-ustekinumab-in-head-to-head-study-in-crohns-disease-301924034.html

" Psychological stress is known to worsen the gut inflammation caused by certain bowel diseases. Now scientists have found out why. New research1 outlines a sweeping narrative that begins with chemical cues produced in the brain and ends with immune cells in the gut — a sequence that spells...

Rinvoq: https://www.medpagetoday.com/gastroenterology/inflammatoryboweldisease/104570?xid=nl_mpt_DHE_2023-05-18&eun=g1228878d0r&utm_source=Sailthru&utm_medium=email&utm_campaign=Daily%20Headlines%20Evening%202023-05-18&utm_term=NL_Daily_DHE_dual-gmail-definition A new class of drugs for...

Article https://www.genomeweb.com/microarrays-multiplexing/inflammatory-bowel-disease-genetics-understanding-expands-east-asian?utm_source=Sailthru&utm_medium=email&utm_campaign=GWDN%20Mon%20PM%202023-05-08&utm_term=GW%20Daily%20News%20Bulletin#.ZFlZ33bMKUk The paper...

New study: https://gut.bmj.com/content/early/2023/01/03/gutjnl-2022-327845 "Conclusion Antibiotic exposure is associated with an increased risk of IBD, and was highest among individuals aged 40 years and older. This risk increased with cumulative antibiotic exposure, with antibiotics targeting...

This is very early basic research, but finding the same receptor protein on the surface of both gut and immune cells opens a new approach to treating/curing IBD. This is years or decades away from clinical use, but it is encouraging to see new approaches opening up...

From the article: "Adopting and maintaining a healthy lifestyle may prevent inflammatory bowel disease (IBD), according to findings from an analysis of three prospective U.S. cohort studies, which were validated in three external European cohorts. In the primary analysis, maintaining low...

https://www.mdedge.com/gihepnews/article/257658/gastroenterology/reassuring-data-nsaids-ibd-flares?ecd=WNLPD_GIHEP_221026_mdedge