i have had a seton for the last 3-4 years. it made a HUGE difference. i stopped abscessing all the time and was able to stay that way for a good long time.(i just found out i have 2 new fistulas) i didn't respond to the remicade, but the seton was and is great. it was a bit uncomfortable at first and really hurt for about a week. if you work on your feet all day i would definitely take at least 3-5 days off, especially if you heal slowly. after a while you won't even notice it is there. i used to freak out thinking it was gone because i couldn't feel it. it wasn't gone. in the time that i have had it it has never caused me any issues.