Skyrizi

[trebor-HI]

Anybody familiar with Skyrizi? Stelara was dropped from my insurance company's formulary and there's murmurings about switching me to Skyrizi. Apparently it targets the protein IL-23 as does Stelara. But Stelara targets both IL-12 and IL-23

 

[Scipio]

Anybody familiar with Skyrizi? Stelara was dropped from my insurance company's formulary and there's murmurings about switching me to Skyrizi. Apparently it targets the protein IL-23 as does Stelara. But Stelara targets both IL-12 and IL-23

I have no experience with Skyrizi, but in theory it should work very similarly to Stelara. As you point out, they both act by binding and inhibiting the immune-activating protein IL-23. And based on a lot of research into the mechanisms, IL-23 is thought to be the key protein in question here. IL-12 is sort of "along for the ride" so to speak. Blocking IL-23 is doing the heavy lifting in controlling the overactive immune response of IBD and autoimmune diseases.

However, Skyrizi coverage by your insurance company may not last much longer than Stelara did. I haven't seen any numbers for Skyrizi, but I'm pretty sure that the example of the big bucks made by Janssen with Stelara is not lost on Abbvie. Thus, with Stelara showing the way, I bet Skyrizi will adopt the same greedy pricing strategy.

 

[thike1966]

I had my third infusion of Skyrizi today it it is going well. I find it is about the same amount of taxing feeling as Stelara was. A few moths ago I had surgery where they took my ileum and part pf my colon when they initially went in to repair a hernia around my ileostomy. Thinking I was going in fo an hour surgery and waking up 8 hours later with a very bloated stomach was a big surprise, but I am feeling so much better and the switch to Skyrizi has been going great. Three infusions at an infusion center and my next doses I will self administer. I am not sure how I will do this, I assume it will be injected like Humira.

I've been on literally every other drug, from, including Renvoke, which I got off dose on due to surgery. So far, I am very pleased and dosing every few months also makes it easier.

Good luck and feel free ti message me if you have more questions.

 

[Hera]

Do you know if is Stelara out of market or something? Any problem with Stelara or only insurance business ?

 

[Scipio]

Do you know if is Stelara out of market or something? Any problem with Stelara or only insurance business ?

There is no shortage of Stelara as far as I know, if that's what you're asking. I get my shipment every 56 days with no problem.

 

[momsa]

An IBD doctor we consulted with said that Skyrizi can be successful even with people that Stelara didn't help. I was surprised to learn this and I'm not sure why this would be - it all seems to be very complicated.

 

[Scipio]

An IBD doctor we consulted with said that Skyrizi can be successful even with people that Stelara didn't help. I was surprised to learn this and I'm not sure why this would be - it all seems to be very complicated.

The patient may have developed antibodies against Stelara that block its action (although this isn't very common, it does occur), and Skyrizi avoids this because it is a different protein.

But it's really not all that unusual among IBD biologic drugs that bind the same protein for one drug to work for a patient and another, seemingly the same, to fail. Remicade and Humira for example - both bind TNF but it's not uncommon to see one work and the other fail for a given Crohn's patient.

 

[thike1966]

Skyrizi is working great for me right now.

With my past doctors, wanting me to be on Stelara from the beginning, I suspect many of my other drugs were working too, but when I got C-Diff 6 times, it didn't matter what drug I was on, I flared. When a close family member or friend passed away, I flared. It seems that my former doctors sort of wanted me to fail up to getting Stelara approved by insurance, which was a disconnect for what was truly the best course for me.

Now I have a great team and it's about whatever will work best for me. Skyrizi is now the answer. But we will keep our options open as always.

Crohn's and our responses to the different drugs can be as varied is all of our personalities. Crohn's drugs are getting better and hopefully so are all of us are getting going to get better too. I have a pharmacy tech I know who's brother has been on Remicade for many years and it's working just fine. I say, good for him.

Crohn's personalities are just like each one of us and very unique, some a lot more than others.

Whoever you are, you are the very most important and special person that you will always wake up with.

Our, oh so unfortunate companion in life, Crohn's disease, the classic used car guy who takes advantage of whatever he can to close deals, no matter what lowly customers want or need. Crohn's waiting in the dim lit parking lot, ready to strike whenever and wherever it can.

For some of us, it is sometimes like internal swarms of steroid infused mosquitos.

However different we may be, what we have in common is all the more.......

 

[Grandma McB]

I am scheduled to have my first Skyrizi infusion on the 29th. A am a bit worried about this one. I am fighting a cold right now and hope to be over it by the 29th. I have been on Humira twice and Entyvio with no problems other than being tired. Any helpful information from anyone that has gone thru this would be wonderful. Thank you

 

[asadmom]

Skyrizi is working great for me right now.

With my past doctors, wanting me to be on Stelara from the beginning, I suspect many of my other drugs were working too, but when I got C-Diff 6 times, it didn't matter what drug I was on, I flared. When a close family member or friend passed away, I flared. It seems that my former doctors sort of wanted me to fail up to getting Stelara approved by insurance, which was a disconnect for what was truly the best course for me.

Now I have a great team and it's about whatever will work best for me. Skyrizi is now the answer. But we will keep our options open as always.

Crohn's and our responses to the different drugs can be as varied is all of our personalities. Crohn's drugs are getting better and hopefully so are all of us are getting going to get better too. I have a pharmacy tech I know who's brother has been on Remicade for many years and it's working just fine. I say, good for him.

Crohn's personalities are just like each one of us and very unique, some a lot more than others.

Whoever you are, you are the very most important and special person that you will always wake up with.

Our, oh so unfortunate companion in life, Crohn's disease, the classic used car guy who takes advantage of whatever he can to close deals, no matter what lowly customers want or need. Crohn's waiting in the dim lit parking lot, ready to strike whenever and wherever it can.

For some of us, it is sometimes like internal swarms of steroid infused mosquitos.

However different we may be, what we have in common is all the more.......

I really like your analogy of Crohn's having different personalities as humans. Some fight hard, some not so much, some prefer certain foods, some back away mysteriously, some are full of energy and life. This is great. I am gonna ask the researchers which one we should take on first.