Thanks for the concern. I have not yet taken the plunge I mentioned. My day started out too hectic for me to even consider starting something new.
And no, it is not the Tempol brand of analgesic that has paracetamol. It is the redox recylcling nitroxide – basically an antioxidant.
And yes, it has definitely been studied on humans as well as used in clinical practice with results published in multiple peer-reviewed journals.
There are literally hundreds of animal studies so perhaps the human studies are lost in the search results. Some of those peer-reviewed articles are available only through subscriptions. Some are fairly recent.
One article came out last fall in Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease on Tempol used in clinical practice for Parkinson’s disease.
One article contains a single case report on improvement in Crohn’s disease.
One published last month by researchers at the University of Oregon in another peer-reviewed journal (the American Journal of Physiology - Heart and Circulatory Physiology) talks about its use on teenagers in a trial to assess its ability to reduce oxidative stress by increased nitric oxide production.
There is another peer-review paper on a formulation with Tempol as the active ingredient for an eye drop for macular degeneration – and that formulation was moving into phase 3 human clinical trials when the company ran out of funds. I can not find any other information on that company.
There are other clinical trials noted in clinicaltrials.gov – most notably on skin protection during radiation and chemotherapy in anal cancer.
Sometimes you have to search via chemical name or a formula number that was assigned to the compound in the clinical trial. It is even known by a different name when cited in Australian journals and patents. I don’t know why.
A google search shows literally hundreds of patents on its use in humans. Most uses relate to free radical stress.
US patent US20120115905 reports on results in clinical practice on human subjects and gives dosing. There are also patents for Crohn’s and IBS.
I was just asking if anyone has had experience with it or knew anyone who used it. I am unable to use most of the conventional treatments for one reason or another – so I keep searching -- and losing weight.
I remember reading a study where the people who use Tempol for alopecia do get a certain amount in their system from topical application. I wonder if they notice any improvements in other health conditions. But maybe the topical dose is not enough to produce a systemic effect.
If it protects skin near the anus from radiation and chemotherapy burns, I can’t help but wonder what it would do for Crohn’s.
